Singh Divya, Upadhyay Ghanshyam, Srivastava Rakesh K, Shankar Sharmila
Department of Biology, City College of New York, 160 Convent Avenue, New York, NY 10031, USA.
Kansas City VA Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA.
Biochim Biophys Acta. 2015 Aug;1856(1):13-27. doi: 10.1016/j.bbcan.2015.04.003. Epub 2015 May 11.
Pancreatic cancer (PC) is the fourth leading cause of cancer-related death in United States. Efforts have been made towards the development of the viable solution for its treatment with constrained accomplishment because of its complex biology. It is well established that pancreatic cancer stem cells (CSCs), albeit present in a little count, contribute incredibly to PC initiation, progression, and metastasis. Customary chemo and radiotherapeutic alternatives, however, expands general survival, the related side effects are the significant concern. Amid the most recent decade, our insight about molecular and cellular pathways involved in PC and role of CSCs in its progression has increased enormously. Presently the focus is to target CSCs. The herbal products have gained much consideration recently as they, usually, sensitize CSCs to chemotherapy and target molecular signaling involved in various tumors including PC. Some planned studies have indicated promising results proposing that examinations in this course have a lot to offer for the treatment of PC. Although preclinical studies uncovered the importance of herbal products in attenuating pancreatic carcinoma, limited studies have been conducted to evaluate their role in clinics. The present review provides a new insight to recent advances in pancreatic cancer biology, treatment and current status of herbal products in its anticipation.
胰腺癌（PC）是美国癌症相关死亡的第四大主要原因。由于其生物学特性复杂，人们一直在努力开发可行的治疗方案，但成效有限。众所周知，胰腺癌干细胞（CSCs）尽管数量很少，却对胰腺癌的发生、发展和转移起着极大的作用。然而，传统的化疗和放疗方案虽然能延长总体生存期，但相关的副作用却令人担忧。在过去十年中，我们对胰腺癌相关分子和细胞途径以及癌症干细胞在其发展过程中的作用的认识有了极大的提高。目前的重点是靶向癌症干细胞。草药产品最近受到了很多关注，因为它们通常能使癌症干细胞对化疗敏感，并靶向包括胰腺癌在内的各种肿瘤中涉及的分子信号传导。一些规划中的研究已经显示出有前景的结果，表明在这个领域的研究对胰腺癌的治疗有很大帮助。尽管临床前研究揭示了草药产品在减轻胰腺癌方面的重要性，但评估其在临床中作用的研究却很有限。本综述为胰腺癌生物学、治疗的最新进展以及草药产品在这方面的现状提供了新的见解。
