Nader Karim
Psychology Department, McGill University, 1205 Dr. Penfield Ave, Montreal, QC, Canada, H3A 1B1,
Handb Exp Pharmacol. 2015;228:249-70. doi: 10.1007/978-3-319-16522-6_9.
Research on the reconsolidation effect was greatly revitalized by the highly analytic demonstration of memory reconsolidation (Nader et al. Nature 406:722-726, 2000) in a well-defined behavioral protocol (auditory fear conditioning in the rat). Since this study, reconsolidation has been demonstrated in hundreds of studies over a range of species, tasks, and amnesic agents. Evidence for reconsolidation does not come solely from the behavioral level of analysis. Cellular and molecular correlates of reconsolidation have also been found. In this chapter, I will first define the evidence on which reconsolidation is concluded to exist. I will then discuss some of the conceptual issues facing the field in determining when reconsolidation does and does not occur. Lastly I will explain the clinical implications of this effect.
通过在一个明确的行为范式（大鼠听觉恐惧条件反射）中对记忆重新巩固进行高度分析性的论证（Nader等人，《自然》406:722 - 726，2000），重新巩固效应的研究得到了极大的复兴。自这项研究以来，在一系列物种、任务和失忆剂中，已有数百项研究证明了重新巩固现象。重新巩固的证据并非仅仅来自行为层面的分析。还发现了重新巩固的细胞和分子相关因素。在本章中，我将首先界定据以得出重新巩固存在这一结论的证据。然后我将讨论该领域在确定重新巩固何时发生以及何时不发生时所面临的一些概念性问题。最后，我将解释这一效应的临床意义。
