Pucci Marzia, Bravatà Valentina, Forte Giusi Irma, Cammarata Francesco Paolo, Messa Cristina, Gilardi Maria Carla, Minafra Luigi
Institute of Bioimaging and Molecular Physiology, National Research Council (IBFM-CNR) -LATO, Cefalù (PA), Italy.
Institute of Bioimaging and Molecular Physiology, National Research Council (IBFM-CNR) -LATO, Cefalù (PA), Italy Department of Health Sciences, Tecnomed Foundation, University of Milano-Bicocca, Milan, Italy Nuclear Medicine Center, San Gerardo Hospital, Monza, Italy.
Cancer Genomics Proteomics. 2015 May-Jun;12(3):143-52.
Breast cancer (BC) recovery has increased in recent years thanks to efforts of Omics-based research in this field. However, despite the important results obtained, BC remains a complex multifactorial pathology that is difficult to treat appropriately. Caveolin-1 (CAV1), the basic constituent protein of specialized plasma membrane invaginations called caveolae, is emerging as a potential therapeutic biomarker in BC. This factor may modulate BC response to chemotherapy and radiation therapy. In addition, recent reports describe the key role of CAV1 during cell response to oxidative stress. The aim of the present review was to describe the biological roles of CAV1 in BC considering its contrasting dual functions as an oncogene and as a tumor suppressor. In addition, we report on how CAV1 may contribute to tumor cell response to ionizing radiation treatment. Finally, new roles of CAV1 in BC both on epithelium and stroma may be useful as prognostic indicators for patient treatment and help clinicians in the selection of the best personalized therapy.
近年来，由于该领域基于组学的研究工作，乳腺癌（BC）的康复情况有所改善。然而，尽管取得了重要成果，但BC仍然是一种复杂的多因素病理学疾病，难以得到恰当治疗。小窝蛋白-1（CAV1）是称为小窝的特殊质膜内陷的基本组成蛋白，正成为BC中一种潜在的治疗生物标志物。该因子可能调节BC对化疗和放疗的反应。此外，最近的报告描述了CAV1在细胞对氧化应激反应中的关键作用。本综述的目的是描述CAV1在BC中的生物学作用，考虑其作为癌基因和肿瘤抑制因子的相反双重功能。此外，我们报告了CAV1如何可能有助于肿瘤细胞对电离辐射治疗的反应。最后，CAV1在BC上皮和基质中的新作用可能作为患者治疗的预后指标有用，并帮助临床医生选择最佳的个性化治疗。
