Eliyatkin Nuket, Aktas Safiye, Diniz Gulden, Ozgur Halil Hakan, Ekin Zubeyde Yildirim, Kupelioglu Ali
Pathology Department, Adnan Menderes University Medical Faculty, Aydin, Turkey.
Basic Oncology Department, Dokuz Eylul University Oncology Institute, Izmir, Turkey.
Pathol Oncol Res. 2018 Jan;24(1):59-65. doi: 10.1007/s12253-017-0212-8. Epub 2017 Feb 24.
Caveolin-1 (Cav-1) is well known as a principal scaffolding protein of caveolae which are specialized plasma membrane structures. The role of Cav-1 in tumorigenesis of breast cancers is relatively less studied. The aim of the present study is to describe the biological roles of Cav-1 in breast cancers considering its contrasting dual functions as an oncogene and as a tumor suppressor. This study included 71 females with breast cancer who had been histopathologically diagnosed in Private Gunes Pathology Laboratory between the years 2007, and 2012. The mean age is 52.48 ± 12.8 years. Patients were followed up for a mean period of 47.97 ± 20.48 months. We didn't determine Cav-1 positive tumor cells. In 36 cases (50.7%), there were stromal expressions of Cav-1. In the statistical analysis, there was a statistically significant correlation between Cav-1 expression and ER (p = 0.033), metastasis (p = 0.005), lymphatic invasion (p = 0.000), nodal metastasis (p = 0,003), perinodal invasion (p = 0.003), metastasis (p = 0.005) and survival (p = 0.009). We found that Cav-1 expression is associated with tumor size, histological grade, lymph node involvement. Accordingly, we have suggested that Cav-1 may be a predictive biomarker for breast cancer.
小窝蛋白-1（Cav-1）作为小窝的主要支架蛋白而广为人知，小窝是特殊的质膜结构。Cav-1在乳腺癌发生中的作用相对研究较少。本研究的目的是鉴于Cav-1作为癌基因和肿瘤抑制基因的双重相反功能，描述其在乳腺癌中的生物学作用。本研究纳入了2007年至2012年间在私立居内什病理实验室经组织病理学诊断的71例乳腺癌女性患者。平均年龄为52.48±12.8岁。患者平均随访47.97±20.48个月。我们未检测到Cav-1阳性肿瘤细胞。在36例（50.7%）病例中，存在Cav-1的间质表达。在统计分析中，Cav-1表达与雌激素受体（ER）（p = 0.033）、转移（p = 0.005）、淋巴管浸润（p = 0.000）、淋巴结转移（p = 0.003）、结周浸润（p = 0.003）、转移（p = 0.005）及生存（p = 0.009）之间存在统计学显著相关性。我们发现Cav-1表达与肿瘤大小、组织学分级、淋巴结受累情况相关。因此，我们认为Cav-1可能是乳腺癌的一种预测性生物标志物。
