PTX3 多态性与实体器官移植后侵袭性霉菌感染。
PTX3 Polymorphisms and Invasive Mold Infections After Solid Organ Transplant.
机构信息
Infectious Diseases Service, University Hospital and University of Lausanne.
Service of Transplantation and Service of Infectious Diseases, University Hospitals of Geneva.
出版信息
Clin Infect Dis. 2015 Aug 15;61(4):619-22. doi: 10.1093/cid/civ386. Epub 2015 May 14.
PMID:25977268
Abstract
Donor PTX3 polymorphisms were shown to influence the risk of invasive aspergillosis among hematopoietic stem cell transplant recipients. Here, we show that PTX3 polymorphisms are independent risk factors for invasive mold infections among 1101 solid organ transplant recipients, thereby strengthening their role in mold infection pathogenesis and patients' risk stratification.
摘要
供者 PTX3 多态性被证明影响造血干细胞移植受者侵袭性曲霉病的风险。在这里，我们表明 PTX3 多态性是 1101 例实体器官移植受者侵袭性霉菌感染的独立危险因素，从而加强了它们在霉菌感染发病机制和患者危险分层中的作用。
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