Institut Pasteur, Immunobiology of Aspergillus, Université de Paris Cité, 75015, Paris, France.
Laboratoire de Parasitologie-Mycologie, AP-HP, Hôpital Saint-Louis, 75010, Paris, France.
Mycopathologia. 2023 Oct;188(5):603-621. doi: 10.1007/s11046-023-00742-0. Epub 2023 Jun 8.
Aspergillus fumigatus is one the most ubiquitous airborne opportunistic human fungal pathogens. Understanding its interaction with host immune system, composed of cellular and humoral arm, is essential to explain the pathobiology of aspergillosis disease spectrum. While cellular immunity has been well studied, humoral immunity has been poorly acknowledge, although it plays a crucial role in bridging the fungus and immune cells. In this review, we have summarized available data on major players of humoral immunity against A. fumigatus and discussed how they may help to identify at-risk individuals, be used as diagnostic tools or promote alternative therapeutic strategies. Remaining challenges are highlighted and leads are given to guide future research to better grasp the complexity of humoral immune interaction with A. fumigatus.
烟曲霉是最普遍存在的空气中机会性人类真菌病原体之一。了解其与宿主免疫系统的相互作用，该免疫系统由细胞和体液臂组成，对于解释曲霉病疾病谱的病理生物学至关重要。虽然细胞免疫已经得到了很好的研究，但体液免疫却被低估了，尽管它在连接真菌和免疫细胞方面起着至关重要的作用。在这篇综述中，我们总结了针对烟曲霉体液免疫的主要参与者的现有数据，并讨论了它们如何帮助识别高危个体，用作诊断工具或促进替代治疗策略。突出了剩余的挑战，并提供了指导，以引导未来的研究，以更好地掌握与烟曲霉的体液免疫相互作用的复杂性。
