Spiliopoulos Konstantinos, Peschos Dimitrios, Batistatou Anna, Ntountas Ioannis, Agnantis Niki, Kitsos Georgios
Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece
Department of Physiology, University Hospital of Ioannina, Ioannina, Greece.
In Vivo. 2015 May-Jun;29(3):309-17.
Tumor cell vasculogenic mimicry refers to the formation of tumor cell-lined vessels that contribute to tumor neovascularization and nutrient and oxygen supply. These tumor cells express many endothelial and stem cell markers, resulting in them having a unique phenotype. This phenomenon is observed in a variety of neoplasms, such as glioblastomas and sarcomas, as well as breast, ovarian, liver and lung carcinomas. It is also evident in melanocytic lesions, regardless of their benign or malignant nature. The biochemical and molecular events that regulate vasculogenic mimicry provide opportunities for development of novel forms of tumor-targeted treatments. Furthermore, the presence of this process in a tumor might have prognostic implications.
肿瘤细胞血管生成拟态是指由肿瘤细胞排列形成的血管，这些血管有助于肿瘤新生血管形成以及营养和氧气供应。这些肿瘤细胞表达多种内皮细胞和干细胞标志物，使其具有独特的表型。在多种肿瘤中都观察到了这种现象，如胶质母细胞瘤、肉瘤以及乳腺癌、卵巢癌、肝癌和肺癌。在黑素细胞性病变中也很明显，无论其为良性还是恶性。调节血管生成拟态的生化和分子事件为开发新型肿瘤靶向治疗方法提供了机会。此外，肿瘤中这一过程的存在可能具有预后意义。
