呼吸道合胞病毒和人偏肺病毒感染人上皮细胞后的黏蛋白差异表达
Differential mucin expression by respiratory syncytial virus and human metapneumovirus infection in human epithelial cells.
作者信息
Baños-Lara Ma Del Rocío, Piao Boyang, Guerrero-Plata Antonieta
机构信息
Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA ; Center for Experimental Infectious Disease Research, Louisiana State University, Baton Rouge, LA 70803, USA.
出版信息
Mediators Inflamm. 2015;2015:347292. doi: 10.1155/2015/347292. Epub 2015 Apr 22.
Mucins (MUC) constitute an important component of the inflammatory and innate immune response. However, the expression of these molecules by respiratory viral infections is still largely unknown. Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are two close-related paramyxoviruses that can cause severe low respiratory tract disease in infants and young children worldwide. Currently, there is not vaccine available for neither virus. In this work, we explored the differential expression of MUC by RSV and hMPV in human epithelial cells. Our data indicate that the MUC expression by RSV and hMPV differs significantly, as we observed a stronger induction of MUC8, MUC15, MUC20, MUC21, and MUC22 by RSV infection while the expression of MUC1, MUC2, and MUC5B was dominated by the infection with hMPV. These results may contribute to the different immune response induced by these two respiratory viruses.
黏蛋白（MUC）是炎症和固有免疫反应的重要组成部分。然而，呼吸道病毒感染对这些分子表达的影响仍 largely 未知。呼吸道合胞病毒（RSV）和人偏肺病毒（hMPV）是两种密切相关的副粘病毒，可在全球范围内导致婴幼儿严重的下呼吸道疾病。目前，这两种病毒均无可用疫苗。在本研究中，我们探讨了 RSV 和 hMPV 在人上皮细胞中对 MUC 的差异表达。我们的数据表明，RSV 和 hMPV 对 MUC 的表达差异显著，因为我们观察到 RSV 感染对 MUC8、MUC15、MUC20、MUC21 和 MUC22 的诱导更强，而 MUC1、MUC2 和 MUC5B 的表达则以 hMPV 感染为主导。这些结果可能有助于解释这两种呼吸道病毒诱导的不同免疫反应。
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