慢性支气管哮喘患儿细胞内镁水平、肺功能与哮喘控制水平之间的关系

Relationship between Intracellular Magnesium Level, Lung Function, and Level of Asthma Control in Children with Chronic Bronchial Asthma.

作者信息

Sein Htwe Htwe, Whye Lian Cheah, Juan Loong Kok, Sl Ng Josephine, Rahardjai Andy, Sultan Mohamed Ameenudeen

机构信息

Department of Paediatric, Faculty of Medicine & Health Sciences, Universiti Malaysia Sarawak, Lot 77, Jalan Tun Ahmad Zaidi Adruce, 93150 Kuching, Sarawak, Malaysia.

Department of Community Medicine & Public Health, Faculty of Medicine & Health Sciences, Universiti Malaysia Sarawak, Lot 77, Jalan Tun Ahmad Zaidi Adruce, 93150 Kuching, Sarawak, Malaysia.

出版信息

Malays J Med Sci. 2014 Sep-Oct;21(5):30-6.

PMID:25977631

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4418123/

Abstract

BACKGROUND

This study aimed to determine the intracellular (red blood cell (RBC)) magnesium levels in children with chronic bronchial asthma and to determine the relationship between the magnesium level and peak expiratory flow rate (PEFR), type of asthma treatment, and level of asthma control.

METHODS

A cross-sectional study was conducted at the Paediatric Clinic, Sarawak General Hospital. A total of 100 children, aged 6-12 years with chronic bronchial asthma, were recruited according to the study criteria. Venous blood samples were obtained to measure the intracellular (RBC) magnesium level using the GBC Avanta Flame Atomic Absorption Spectrophotometer.

RESULTS

Mean age was 8.57 (SD 1.18) years, and 63% of the participants were male. Mean duration of asthma was 62.2 (SD 32.3) months. A normal intracellular magnesium level was found in 95% of the participants, with a mean of 2.27 (SD 0.33) mmol/L. Two-thirds of the participants had a normal peak flow expiratory rate (> 80% of predicted value). About 85% were using both reliever and controller. Almost half of the participants (49%) had chronic asthma that was well-controlled. No significant relationship was found between magnesium level and age (r = -0.089, P = 0.379), gender (t = 0.64, P = 0.52), duration of asthma (r = -0.03, P = 0.74), PEFR (t = 0.41, P = 0.68), current level of asthma control (t = 0.02, P = 0.97), and current treatment (t = 0.414, P = 0.680).

CONCLUSION

There was no significant intracellular magnesium deficiency in children with chronic bronchial asthma. There was no significant relationship between therapeutic medications used for treatment of children with chronic asthma and intracellular magnesium levels.

摘要

背景

本研究旨在测定慢性支气管哮喘患儿的细胞内（红细胞）镁水平，并确定镁水平与呼气峰值流速（PEFR）、哮喘治疗类型及哮喘控制水平之间的关系。

方法

在砂拉越综合医院儿科诊所进行了一项横断面研究。根据研究标准，共招募了100名6至12岁的慢性支气管哮喘患儿。采集静脉血样，使用GBC Avanta火焰原子吸收分光光度计测量细胞内（红细胞）镁水平。

结果

平均年龄为8.57（标准差1.18）岁，63%的参与者为男性。哮喘平均病程为62.2（标准差32.3）个月。95%的参与者细胞内镁水平正常，平均值为2.27（标准差0.33）mmol/L。三分之二的参与者呼气峰值流速正常（>预测值的80%）。约85%的参与者同时使用缓解药物和控制药物。近一半的参与者（49%）患有控制良好的慢性哮喘。未发现镁水平与年龄（r = -0.089，P = 0.379）、性别（t = 0.64，P = 0.52）、哮喘病程（r = -0.03，P = 0.74）、PEFR（t = 0.41，P = 0.68）、当前哮喘控制水平（t = 0.02，P = 0.97）及当前治疗（t = 0.414，P = 0.680）之间存在显著关系。