Jung Tae-Young, Kim Young-Hee, Jung Shin, Baek Hee-Jo, Lee Kyung-Hwa
Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital & Medical School, Hwasun, Korea.
Department of Pediatrics, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital & Medical School, Hwasun, Korea.
Brain Tumor Res Treat. 2015 Apr;3(1):44-7. doi: 10.14791/btrt.2015.3.1.44. Epub 2015 Apr 29.
In this study, we reviewed the clinical characteristics of five cases of subependymal giant cell astrocytoma (SEGA) at our hospital between May 1997 and July 2012. The median age was 18 years old (range, 8 to 26). The clinical symptoms were presented as seizure in two patients and headache in three patients. All the tumors were located near the foramen of Monro. The median size of the tumors was 2.5 cm (range, 1.9-4.0). Two patients showed the solitary lesion, and three had subependymal nodules and cortical tubers. The median follow-up duration was 7.4 years (range, 2.0-14.3). Three patients were associated with the tuberous sclerosis complex (TSC). Four patients showed the SEGA at the first presentation and one patient experienced the 1.9 cm-sized growing mass during 7.7 years follow-up after the diagnosis of the TSC. The mass was totally removed in four patients and subtotally in one. Postoperatively, one patient took the medication for the seizure, which was controllable. The subtotally removed mass showed the recurrence postoperative 4.1 years later, and the recurred mass was stable for 4.5 years after the recurrence. The clinical follow-up study of the SEGA showed an indolent behavior before and after the surgery.
在本研究中，我们回顾了1997年5月至2012年7月间我院收治的5例室管膜下巨细胞星形细胞瘤（SEGA）的临床特征。中位年龄为18岁（范围8至26岁）。临床症状表现为2例患者出现癫痫发作，3例患者出现头痛。所有肿瘤均位于孟氏孔附近。肿瘤的中位大小为2.5 cm（范围1.9 - 4.0 cm）。2例患者表现为孤立性病变，3例有室管膜下结节和皮质结节。中位随访时间为7.4年（范围2.0 - 14.3年）。3例患者与结节性硬化症（TSC）相关。4例患者初诊时即发现SEGA，1例患者在TSC诊断后的7.7年随访期间出现了一个大小为1.9 cm的生长性肿块。4例患者肿瘤完全切除，1例次全切除。术后，1例患者服用抗癫痫药物，病情可控。次全切除的肿块在术后4.1年复发，复发后肿块在4.5年内保持稳定。SEGA的临床随访研究显示，手术前后其行为表现较为惰性。
