Cooper Dermot M F
Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom.
Cell Calcium. 2015 Oct;58(4):368-75. doi: 10.1016/j.ceca.2015.04.004. Epub 2015 Apr 22.
One of the longest-standing effects of SOCE is in its selective regulation of Ca(2+)-sensitive adenylyl cyclase (AC) activity in non-excitable cells. Remarkably it was this source of Ca(2+) (SOCE) rather than the apparent magnitude of the Ca(2+)-rise that conferred AC responsiveness. The molecular basis for this dependence is now resolved in the case of adenylyl cyclase 8 (AC8). Sensors for Ca(2+) and cAMP targeted to ACs have been particularly useful in dissecting the influences upon and composition of what turn out to be signalling microdomains centred on ACs. A number of physiological processes depend on the regulation by SOCE of ACs, but the issue is under-studied. Here I will expand on these topics and point to some immediate unresolved questions.
钙库操纵性钙内流（SOCE）最持久的效应之一是其对非兴奋性细胞中钙（Ca2+）敏感的腺苷酸环化酶（AC）活性的选择性调节。值得注意的是，正是这种钙（Ca2+）来源（SOCE）而非Ca2+升高的明显幅度赋予了AC反应性。现在，在腺苷酸环化酶8（AC8）的情况下，这种依赖性的分子基础已得到解决。靶向AC的Ca2+和环磷酸腺苷（cAMP）传感器在剖析对以AC为中心的信号微区的影响及其组成方面特别有用。许多生理过程依赖于SOCE对AC的调节，但这个问题研究不足。在这里，我将详细阐述这些主题，并指出一些尚未解决的紧迫问题。
