Kandail Harkamaljot, Hamady Mohamad, Xu Xiao Yun
Department of Chemical Engineering, Imperial College London, UK.
Department of Interventional Radiology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.
J Endovasc Ther. 2015 Aug;22(4):578-90. doi: 10.1177/1526602815587261. Epub 2015 May 15.
To report a computational study assessing the hemodynamic outcomes of branched stent-grafts (BSGs) for different anatomic variations.
Idealized models of BSGs and fenestrated stent-grafts (FSGs) were constructed with different visceral takeoff angles (ToA) and lateral aortic neck angles. ToA was defined as the angle between the centerlines of the main stent-graft and side branch, with 90° representing normal alignment, and 30° and 120° representing angulated side branches. Computational simulations were performed by solving the conservation equations governing the blood flow under physiologically realistic conditions.
The largest renal flow recirculation zones (FRZs) were observed in FSGs at a ToA of 30°, and the smallest FRZ was also found in FSGs (at a ToA of 120°). For straight-neck stent-grafts with a ToA of 90°, mean flow in each renal artery was 0.54, 0.46, and 0.62 L/min in antegrade BSGs, retrograde BSGs, and FSGs, respectively. For angulated stent-grafts, the corresponding values were 0.53, 0.48, and 0.63 L/min. All straight-neck stent-grafts experienced equal cycle-averaged displacement forces of 1.25, 1.69, and 1.95 N at ToAs of 30°, 90°, and 120°, respectively. Angulated main stent-grafts experienced an equal cycle-averaged displacement force of 3.6 N.
The blood flow rate in renal arteries depends on the configuration of the stent-graft, with an FSG giving maximum renal flow and a retrograde BSG resulting in minimum renal flow. Nevertheless, the difference was small, up to 0.09 L/min. Displacement forces exerted on stent-grafts are very sensitive to lateral neck angle but not on the configuration of the stent-graft.
报告一项计算研究,评估不同解剖变异情况下分支型覆膜支架(BSG)的血流动力学结果。
构建具有不同内脏分支起始角度(ToA)和主动脉颈侧方角度的理想化BSG和开窗型覆膜支架(FSG)模型。ToA定义为主干覆膜支架中心线与侧支中心线之间的夹角,90°代表正常对齐,30°和120°代表成角侧支。通过求解在生理现实条件下控制血流的守恒方程进行计算模拟。
在ToA为30°的FSG中观察到最大的肾血流再循环区(FRZ),在ToA为120°的FSG中也发现最小的FRZ。对于ToA为90°的直颈覆膜支架,顺行BSG、逆行BSG和FSG中各肾动脉的平均血流量分别为0.54、0.46和0.62 L/分钟。对于成角覆膜支架,相应值分别为0.53、0.48和0.63 L/分钟。所有直颈覆膜支架在ToA为30°、90°和120°时分别承受相等的周期平均位移力,大小为1.25、1.69和1.95 N。成角主干覆膜支架承受相等的周期平均位移力为3.6 N。
肾动脉中的血流速率取决于覆膜支架的构型,FSG产生最大肾血流,逆行BSG导致最小肾血流。然而,差异很小,最大为0.09 L/分钟。施加在覆膜支架上的位移力对颈侧方角度非常敏感,但对覆膜支架的构型不敏感。