Campa Carlo C, Franco Irene, Hirsch Emilio
Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.
Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.
FEBS Lett. 2015 Jun 22;589(14):1552-8. doi: 10.1016/j.febslet.2015.05.001. Epub 2015 May 12.
The spatial restriction of phosphorylated phosphoinositides generated downstream activated membrane receptors is critical for proper cell response to environmental cues. The α isoform of class II PI3Ks, PI3K-C2α, has emerged as a modulator of receptor localization, acting both in the control of receptor endocytosis and resensitization. This unexpectedly versatile enzyme was found to differentially produce two distinct 3-phosphorylated phosphoinositides and to selectively control distinct steps of vesicular traffic such as endocytosis and recycling. This review focuses on the latest discoveries regarding PI3K-C2α function in vesicle trafficking and its impact on cell biology and mammalian embryonic development.
由活化的膜受体产生的磷酸化磷脂酰肌醇的空间限制对于细胞对环境信号的正确反应至关重要。II类磷脂酰肌醇3-激酶（PI3K）的α亚型，即PI3K-C2α，已成为受体定位的调节剂，在受体的内吞作用和再敏化控制中均发挥作用。人们发现这种具有意想不到的多功能性的酶能差异地产生两种不同的3-磷酸化磷脂酰肌醇，并选择性地控制囊泡运输的不同步骤，如内吞作用和再循环。本综述聚焦于PI3K-C2α在囊泡运输中的功能及其对细胞生物学和哺乳动物胚胎发育影响的最新发现。
