Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, 10126 Turin, Italy.
Biomolecules. 2019 Mar 15;9(3):104. doi: 10.3390/biom9030104.
Phosphorylation of inositol phospholipids by the family of phosphoinositide 3-kinases (PI3Ks) is crucial in controlling membrane lipid composition and regulating a wide range of intracellular processes, which include signal transduction and vesicular trafficking. In spite of the extensive knowledge on class I PI3Ks, recent advances in the study of the three class II PI3Ks (PIK3C2A, PIK3C2B and PIK3C2G) reveal their distinct and non-overlapping cellular roles and localizations. By finely tuning membrane lipid composition in time and space among different cellular compartments, this class of enzymes controls many cellular processes, such as proliferation, survival and migration. This review focuses on the recent developments regarding the coordination of membrane trafficking and intracellular signaling of class II PI3Ks through the confined phosphorylation of inositol phospholipids.
磷酸肌醇脂质的磷酸化由磷酸肌醇 3-激酶家族（PI3Ks）控制，对于控制膜脂组成和调节广泛的细胞内过程至关重要，其中包括信号转导和囊泡运输。尽管对 I 类 PI3Ks 有广泛的了解，但最近对三种 II 类 PI3Ks（PIK3C2A、PIK3C2B 和 PIK3C2G）的研究进展揭示了它们独特且不重叠的细胞作用和定位。通过在不同细胞区室之间的时间和空间上精细调节膜脂组成，这类酶控制着许多细胞过程，如增殖、存活和迁移。这篇综述重点介绍了通过限定性磷酸化肌醇磷脂来协调 II 类 PI3Ks 的膜运输和细胞内信号转导的最新进展。
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