PG & Research Department of Chemistry, Government Arts College, Tiruvannamalai, Tamil nadu, India.
PG & Research Department of Chemistry, Muthurangam Government Arts College (Autonomous), Vellore, Tamil nadu, India.
Ecotoxicol Environ Saf. 2015 Nov;121:87-92. doi: 10.1016/j.ecoenv.2015.05.002. Epub 2015 Jun 5.
A conventional and microwave assisted efficient synthesis of diphenyl substituted pyrazole using PEG 600 as green solvent has been described. A relatively shorter reaction time with excellent yield of the piperidine mediated protocol has been attracted economically attractive and eco-friendly. All newly synthesized compounds were characterized by standard spectroscopic techniques viz., UV-visible, FT-IR, (1)H-NMR and Mass spectra. The anti-microbial activities of compounds have also been tested using Minimum Inhibitory Concentration (MIC) method with two different microorganisms Staphylococcus aureus (MTCC3381) and Escherichia coli (MTCC739). The results of the antimicrobial activity revealed that the diphenyl substituted pyrazole derivatives have nice inhibiting nature against both types of bacteria of present investigation than corresponding chalcones. Since, the work has been focused on green chemical approach towards the synthesis, this protocol may be recommended for eco-friendly applications.
采用 PEG 600 作为绿色溶剂，常规法和微波辅助法高效合成了二苯基取代吡唑。哌啶介导的方案具有相对较短的反应时间和出色的收率，具有经济吸引力和环境友好性。所有新合成的化合物均通过标准光谱技术（UV-可见，FT-IR，（1）H-NMR 和质谱）进行了表征。还使用最低抑菌浓度（MIC）方法，用两种不同的微生物金黄色葡萄球菌（MTCC3381）和大肠杆菌（MTCC739）对化合物的抗菌活性进行了测试。抗菌活性的结果表明，与相应的查耳酮相比，二苯基取代吡唑衍生物对本研究中两种类型的细菌均具有良好的抑制作用。由于工作重点是绿色化学方法在合成中的应用，因此该方案可能适用于环保应用。
