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脂肪酸感知与遗传学的最新进展。

Recent advances in fatty acid perception and genetics.

作者信息

Reed Danielle R, Xia Mary B

机构信息

Monell Chemical Senses Center, Philadelphia, PA

Monell Chemical Senses Center, Philadelphia, PA.

出版信息

Adv Nutr. 2015 May 15;6(3):353S-60S. doi: 10.3945/an.114.007005. Print 2015 May.

DOI:10.3945/an.114.007005
PMID:25979508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4424773/
Abstract

This article summarizes new knowledge about the contribution of genetic variation to person-to-person differences underlying some sensory aspects of dietary fatty acids. Receptors on the taste cells of the human tongue arise from genes that have marked variation in DNA sequence, which, in some cases, is associated with differences in how these lipids in foods are perceived. These perceptual differences may affect food selection.

摘要

本文总结了关于基因变异在饮食脂肪酸某些感官方面人与人之间差异中所起作用的新知识。人类舌头上味觉细胞的受体源自DNA序列存在显著变异的基因,在某些情况下,这种变异与食物中这些脂质的感知差异有关。这些感知差异可能会影响食物选择。

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本文引用的文献

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The role of lipolysis in human orosensory fat perception.脂解作用在人体口腔感觉脂肪感知中的作用。
J Lipid Res. 2014 May;55(5):870-82. doi: 10.1194/jlr.M046029. Epub 2014 Mar 31.
2
Preferences for salty and sweet tastes are elevated and related to each other during childhood.儿童期对咸和甜口味的偏好增强,且二者相互关联。
PLoS One. 2014 Mar 17;9(3):e92201. doi: 10.1371/journal.pone.0092201. eCollection 2014.
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Endogenous gustatory responses and gene expression profile of stably proliferating human taste cells isolated from fungiform papillae.从菌状乳头分离的稳定增殖的人类味觉细胞的内源性味觉反应和基因表达谱。
Chem Senses. 2014 May;39(4):359-77. doi: 10.1093/chemse/bju009. Epub 2014 Mar 12.
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Mechanisms and effects of "fat taste" in humans.人类“脂肪味道”的机制与影响。
Biofactors. 2014 May-Jun;40(3):313-26. doi: 10.1002/biof.1162. Epub 2014 Mar 4.
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Sweet taste receptor deficient mice have decreased adiposity and increased bone mass.甜味受体缺陷型小鼠的肥胖程度降低,骨量增加。
PLoS One. 2014 Jan 22;9(1):e86454. doi: 10.1371/journal.pone.0086454. eCollection 2014.
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Detecting fat content of food from a distance: olfactory-based fat discrimination in humans.远距离检测食物的脂肪含量:人类基于嗅觉的脂肪辨别
PLoS One. 2014 Jan 22;9(1):e85977. doi: 10.1371/journal.pone.0085977. eCollection 2014.
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CD36- and GPR120-mediated Ca²⁺ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice.CD36- 和 GPR120 介导的人味蕾细胞中的 Ca²⁺信号转导调节对脂肪酸的差异反应,并在肥胖小鼠中发生改变。
Gastroenterology. 2014 Apr;146(4):995-1005. doi: 10.1053/j.gastro.2014.01.006. Epub 2014 Jan 9.
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