立体定向放射治疗联合免疫治疗：增强放疗在局部和全身治疗中的作用
Stereotactic radiation therapy combined with immunotherapy: augmenting the role of radiation in local and systemic treatment.
作者信息
Sharabi Andrew B, Tran Phuoc T, Lim Michael, Drake Charles G, Deweese Theodore L
出版信息
Oncology (Williston Park). 2015 May;29(5):331-40.
Abstract
Stereotactic radiosurgery and stereotactic body radiation therapy are two contemporary radiation modalities that can treat tumors in any area of the body using highly focused radiation. Recently, immunotherapy has established itself as a viable and powerful anticancer treatment. In this review we detail the rationale supporting a combination of immunotherapy and stereotactic radiation. Additionally, we discuss the evidence for the immune stimulatory effects of focused radiation and the role that radiation may play in enhancing the systemic treatment effects of immunotherapy.
摘要
立体定向放射外科和立体定向体部放射治疗是两种现代放射治疗方式，它们可以使用高度聚焦的辐射来治疗身体任何部位的肿瘤。最近，免疫疗法已成为一种可行且强大的抗癌治疗方法。在本综述中，我们详细阐述了支持免疫疗法与立体定向放射相结合的基本原理。此外，我们还讨论了聚焦辐射的免疫刺激作用的证据以及辐射在增强免疫疗法的全身治疗效果中可能发挥的作用。
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