Karatzanis A, Kalogjera L, Scadding G, Velegrakis S, Kawauchi H, Cingi C, Prokopakis E
Department of Otorhinolaryngology - Head and Neck Surgery, University of Crete School of Medicine, Heraklion, Crete, Greece.
Department of Otorhinolaryngology, University Hospital Centre "Sestre Milosrdnice", Zagreb, Croatia.
Int J Pediatr Otorhinolaryngol. 2015 Jul;79(7):965-8. doi: 10.1016/j.ijporl.2015.02.024. Epub 2015 Feb 28.
Upper airway diseases are extremely common, and a significant proportion of patients are not adequately controlled by contemporary treatment algorithms. The term SCUAD (Severe Chronic Upper Airway Disease) has been previously introduced to describe such cases. However, this term has not been adequately focused on children.
This study aims to address the necessity of the term, as well as further details specifically for children. For this purpose, a review was performed of the current literature, with specific focus on issues regarding SCUAD in children.
Paediatric SCUAD represents a heterogeneous group of patients and has significant clinical and socioeconomic implications. Relevant literature is generally lacking and questions regarding definition and pathogenesis remain unanswered.
Accurate definition and acknowledgement of paediatric SCUAD cases may lead to better design of future clinical and molecular research protocols. This may provide improved understanding of the underlying disease processes, more accurate data regarding socioeconomic burden, and, above all, more successful treatment and prevention strategies.
上气道疾病极为常见，相当一部分患者未被当代治疗方案充分控制。术语“严重慢性上气道疾病（SCUAD）”此前已被引入以描述此类病例。然而，该术语尚未充分关注儿童。
本研究旨在探讨该术语的必要性以及针对儿童的更多具体细节。为此，对当前文献进行了综述，特别关注儿童SCUAD相关问题。
儿科SCUAD代表一组异质性患者，具有重大的临床和社会经济意义。相关文献普遍缺乏，关于定义和发病机制的问题仍未得到解答。
准确界定和认识儿科SCUAD病例可能有助于更好地设计未来的临床和分子研究方案。这可能增进对潜在疾病过程的理解，提供更准确的社会经济负担数据，最重要的是，带来更成功的治疗和预防策略。
