The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage is susceptible to increased weight gain when fed a high-fat diet: Confirmation of a gene-diet interaction.
作者信息
Jelinek David, Castillo Joseph J, Heidenreich Randall A, Garver William S
机构信息
Department of Biochemistry and Molecular Biology, School of Medicine, The University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Department of Pediatrics, School of Medicine, The University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
出版信息
Gene. 2015 Aug 15;568(1):112-3. doi: 10.1016/j.gene.2015.05.025. Epub 2015 May 12.
Abstract
摘要
相似文献
1
The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage is susceptible to increased weight gain when fed a high-fat diet: Confirmation of a gene-diet interaction.基因剂量降低的C57BL/6J尼曼-匹克C1小鼠模型在高脂饮食喂养时易出现体重增加：基因-饮食相互作用的证实。
Gene. 2015 Aug 15;568(1):112-3. doi: 10.1016/j.gene.2015.05.025. Epub 2015 May 12.
2
The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways.尼曼-皮克C1基因与高脂饮食相互作用，通过对中枢能量代谢途径的差异调节来促进体重增加。
Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E183-E194. doi: 10.1152/ajpendo.00369.2016. Epub 2017 May 9.
3
The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage has impaired glucose tolerance independent of body weight.C57BL/6J Niemann-Pick C1 小鼠模型中基因剂量降低会导致葡萄糖耐量受损，与体重无关。
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4
The Niemann-Pick C1 gene is downregulated in livers of C57BL/6J mice by dietary fatty acids, but not dietary cholesterol, through feedback inhibition of the SREBP pathway.膳食脂肪酸通过反馈抑制 SREBP 通路下调 C57BL/6J 小鼠肝脏中的 Niemann-Pick C1 基因，但膳食胆固醇没有，通过反馈抑制 SREBP 通路。
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Decreased Npc1 gene dosage in mice is associated with weight gain.在小鼠中，NPC1 基因剂量的降低与体重增加有关。
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The Niemann-Pick C1 gene interacts with a high-fat diet and modifying genes to promote weight gain.尼曼-皮克C1基因与高脂饮食及修饰基因相互作用，以促进体重增加。
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Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance.NPC1 杂合不足可促进与胰岛素抵抗相关的体重增加和代谢特征。
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Glucosamine enhances body weight gain and reduces insulin response in mice fed chow diet but mitigates obesity, insulin resistance and impaired glucose tolerance in mice high-fat diet.氨基葡萄糖可促进以普通饲料喂养的小鼠体重增加并降低其胰岛素反应，但可减轻高脂饮食小鼠的肥胖、胰岛素抵抗和葡萄糖耐量受损。
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A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele.一种小鼠尼曼-匹克C1 I1061T基因敲入模型概括了最常见的人类疾病等位基因的病理特征。
J Neurosci. 2015 May 27;35(21):8091-106. doi: 10.1523/JNEUROSCI.4173-14.2015.
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Endocr Rev. 2018 Apr 1;39(2):192-220. doi: 10.1210/er.2017-00176.
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The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways.尼曼-皮克C1基因与高脂饮食相互作用，通过对中枢能量代谢途径的差异调节来促进体重增加。
Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E183-E194. doi: 10.1152/ajpendo.00369.2016. Epub 2017 May 9.
本文引用的文献
1
Differential Association of Niemann-Pick C1 Gene Polymorphisms with Maternal Prepregnancy Overweight and Gestational Diabetes.尼曼-皮克C1基因多态性与孕前超重及妊娠期糖尿病的差异关联
J Diabetes Obes. 2015;2(1). doi: 10.15436/2376-0494.15.007.
2
The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage has impaired glucose tolerance independent of body weight.C57BL/6J Niemann-Pick C1 小鼠模型中基因剂量降低会导致葡萄糖耐量受损，与体重无关。
Gene. 2013 Sep 15;527(1):65-70. doi: 10.1016/j.gene.2013.05.080. Epub 2013 Jun 11.
3
Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes.哺乳动物 NPC1 基因可能经历正选择，人类多态性与 2 型糖尿病相关。
BMC Med. 2012 Nov 15;10:140. doi: 10.1186/1741-7015-10-140.
4
Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population.24 种肥胖相关遗传变异对法国人群胰岛素抵抗、胰岛β细胞功能和 2 型糖尿病风险的贡献。
Int J Obes (Lond). 2013 Jul;37(7):980-5. doi: 10.1038/ijo.2012.175. Epub 2012 Oct 23.
5
The role of decreased levels of Niemann-Pick C1 intracellular cholesterol transport on obesity is reversed in the C57BL/6J, metabolic syndrome mouse strain: a metabolic or an inflammatory effect?Niemann-Pick C1 细胞内胆固醇转运水平降低在肥胖中的作用在 C57BL/6J，代谢综合征小鼠品系中被逆转：是代谢作用还是炎症作用？
J Appl Genet. 2012 Aug;53(3):323-30. doi: 10.1007/s13353-012-0099-8. Epub 2012 May 15.
6
Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples.基于人群样本的 GWAS 鉴定的早发性和病态肥胖常见遗传变异的评估。
Int J Obes (Lond). 2013 Feb;37(2):191-6. doi: 10.1038/ijo.2012.34. Epub 2012 Mar 20.
7
Genetic variation in the mouse model of Niemann Pick C1 affects female, as well as male, adiposity, and hepatic bile transporters but has indeterminate effects on caveolae.尼曼匹克 C1 型小鼠模型中的遗传变异影响雌性和雄性肥胖，以及肝胆汁转运体，但对小窝有不确定的影响。
Gene. 2012 Jan 10;491(2):128-34. doi: 10.1016/j.gene.2011.10.010. Epub 2011 Oct 14.
8
Studies of metabolic phenotypic correlates of 15 obesity associated gene variants.15 种肥胖相关基因变异的代谢表型相关研究。
PLoS One. 2011;6(9):e23531. doi: 10.1371/journal.pone.0023531. Epub 2011 Sep 2.
9
Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance.NPC1 杂合不足可促进与胰岛素抵抗相关的体重增加和代谢特征。
Hum Mol Genet. 2011 Jan 15;20(2):312-21. doi: 10.1093/hmg/ddq466. Epub 2010 Oct 29.
10
Decreased Npc1 gene dosage in mice is associated with weight gain.在小鼠中，NPC1 基因剂量的降低与体重增加有关。
Obesity (Silver Spring). 2010 Jul;18(7):1457-9. doi: 10.1038/oby.2009.415. Epub 2009 Nov 12.
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