Sanchis Marta, Capilla Javier, Mayayo Emilio, Pastor Francisco J, Guarro Josep
Unitat de Microbiologia.
Unitat d'Anatomia Patològica, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
Med Mycol. 2015 Aug;53(6):630-5. doi: 10.1093/mmy/myv027. Epub 2015 May 14.
Whereas echinocandins are alternatives for the treatment of invasive aspergillosis, the efficacy of anidulafungin (AFG) against Aspergillus terreus infection has not yet been explored. We have evaluated the in vitro activity, as well as the in vivo efficacy of AFG in neutropenic mice infected by A. terreus species complex. Time-kill studies showed in vitro fungistatic activity of AFG against two strains. AFG at doses of 5 and 10 mg/kg/day significantly reduced the fungal load in kidney of mice, but only the higher dose was able to prolong survival.
尽管棘白菌素是治疗侵袭性曲霉病的替代药物，但阿尼芬净（AFG）针对土曲霉感染的疗效尚未得到研究。我们评估了AFG对土曲霉复合种感染的中性粒细胞减少小鼠的体外活性和体内疗效。时间杀菌研究显示AFG对两株菌株具有体外抑菌活性。5和10mg/kg/天剂量的AFG显著降低了小鼠肾脏中的真菌负荷，但只有较高剂量能够延长生存期。
