Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç, Reus, Spain.
Int J Antimicrob Agents. 2011 Oct;38(4):360-3. doi: 10.1016/j.ijantimicag.2011.06.008. Epub 2011 Aug 6.
In this study, anidulafungin (AFG) showed high in vitro activity against 10 isolates of Aspergillus niger by broth microdilution and disk diffusion methods. The efficacy of AFG at 1, 5 and 10 mg/kg was tested against six of the isolates in a murine model of disseminated infection. AFG was able to reduce mortality, showing survival rates of 70-100%, 60-100% and 30-60% in mice treated with AFG at 10, 5 and 1 mg/kg, respectively. AFG also showed a dose-response efficacy in reducing tissue burden in kidneys and spleen. A parallel experiment demonstrated that administration of AFG did not reduce serum concentrations of galactomannan in mice. Histopathological studies confirmed the efficacy of AFG.
在这项研究中，通过肉汤微量稀释法和药敏纸片扩散法，棘白菌素（AFG）对 10 株黑曲霉分离株表现出很高的体外活性。在播散性感染的小鼠模型中，对其中 6 株分离株进行了 1、5 和 10mg/kg 的 AFG 疗效测试。AFG 能够降低死亡率，在 10、5 和 1mg/kg 的 AFG 治疗组中，小鼠的存活率分别为 70-100%、60-100%和 30-60%。AFG 还显示出在降低肾脏和脾脏组织负荷方面的剂量反应疗效。平行实验表明，AFG 的给药不会降低小鼠血清半乳甘露聚糖浓度。组织病理学研究证实了 AFG 的疗效。
