Silachev D N, Manskikh V N, Gulyaev M V, Pevzner I B, Zorova L D, Babenko V A, Plotnikov E Y, Pirogov Y A, Zorov D B
Patol Fiziol Eksp Ter. 2014 Oct-Dec(4):53-8.
We studied the influence of ischemia/reperfusion of the middle cerebral artery in the rat's brain on the deferred violation of cognitive functions of the brain which are similar to main symptoms observed in the development of Alzheimer's disease. Using 8-hose radial labyrinth we demonstrated that 6 months after incidence of cerebral ischemia a significant impairment of working memory and a decrease in animals the ability to learn are developed. 7 months after focal cerebral ischemia we could observe the accumulation of a mature amyloid peptide and hyperphosphorylated form of the Tau pro- tein in ipsilateral cerebral hemisphere and of the the beta-amyloid peptide precursor in the contralateral hemisphere. Thus, after an experimental stroke in the brain pathological chanres occur as those typical of Alzheimer's disease.
我们研究了大鼠大脑中大脑中动脉缺血/再灌注对大脑认知功能延迟性损害的影响，这种损害类似于阿尔茨海默病发展过程中观察到的主要症状。使用八臂放射状迷宫，我们证明脑缺血发生6个月后，工作记忆出现显著损害，动物学习能力下降。局灶性脑缺血7个月后，我们可以观察到同侧大脑半球成熟淀粉样肽和Tau蛋白的过度磷酸化形式以及对侧半球β淀粉样肽前体的积累。因此，在脑部实验性中风后，会出现阿尔茨海默病典型的病理变化。
