Medical University of Vienna, Department of Surgery, Austria.
Medical University of Vienna, Center for Medical Statistics, Informatics and Intelligent Systems, Austria.
Int J Surg. 2015 Jul;19:42-5. doi: 10.1016/j.ijsu.2015.04.045. Epub 2015 May 15.
In the light of controversial data in the literature, the present study was designed to evaluate potential associations between colonic diverticular disease, constipation and quality of life.
We prospectively enrolled 976 consecutive patients, who participated in the nationwide colorectal cancer screening program in four medical centers between 2008 and 2009. All patients underwent full colonoscopy and completed a standardized questionnaire. The severity of constipation was assessed by the validated Wexner constipation score. Quality of Life (QOL) was evaluated by the SF-12 health score.
The median age was 62 years (range 22-90) and the male to female ratio was 1:1. Colonic diverticular disease was found in 290 participants (30%). Age, body mass index and diabetes mellitus were significantly associated with the presence of diverticular disease (p < 0.0001, p = 0.0007 and p = 0.0178). The median constipation score in patients with diverticular disease was 3 (range 0-18), and comparable to patients without diverticula (p = 0.1073). The physical component summary of the SF-12 was significantly reduced in patients with diverticular disease (p = 0.0038).
This large population based study revealed no association between colonic diverticular disease and constipation. Notably, the presence of diverticular disease significantly impacts quality of life.
鉴于文献中存在有争议的数据，本研究旨在评估结肠憩室病、便秘和生活质量之间的潜在关联。
我们前瞻性地招募了 976 名连续患者，他们参加了 2008 年至 2009 年期间在四个医疗中心进行的全国性结直肠癌筛查计划。所有患者均接受了全结肠镜检查，并完成了标准化问卷。便秘的严重程度通过经过验证的 Wexner 便秘评分进行评估。生活质量 (QOL) 通过 SF-12 健康评分进行评估。
中位年龄为 62 岁（范围 22-90），男女比例为 1:1。290 名参与者（30%）存在结肠憩室病。年龄、体重指数和糖尿病与憩室病的存在显著相关（p<0.0001，p=0.0007 和 p=0.0178）。憩室病患者的中位便秘评分为 3（范围 0-18），与无憩室病患者相当（p=0.1073）。SF-12 的物理成分综合评分在憩室病患者中显著降低（p=0.0038）。
这项基于人群的大型研究表明，结肠憩室病与便秘之间没有关联。值得注意的是，憩室病的存在显著影响生活质量。
