Yazici Cemal, Arslan Deniz Cagil, Abraham Rana, Cushing Kelly, Keshavarzian Ali, Mutlu Ece A
Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, 840 S Wood Street, Suite 718E, Chicago, IL, 60612, USA.
Division of Digestive Diseases and Nutrition, Rush Presbyterian St. Luke's Medical Center, Rush University Medical Center, 1725 W Harrison, Suite 206, Chicago, IL, 60612, USA.
Dig Dis Sci. 2016 Sep;61(9):2648-54. doi: 10.1007/s10620-016-4174-6. Epub 2016 Apr 29.
Diverticulosis and its complications are important healthcare problems in the USA and throughout the Western world. While mechanisms as to how diverticulosis occurs have partially been explored, few studies examined the relationship between colonic gases such as methane and diverticulosis in humans.
This study aimed to demonstrate a significant relationship between methanogenic Archaea and development of diverticulosis.
Subjects who consecutively underwent hydrogen breath test at Rush University Medical Center between 2003 and 2010 were identified retrospectively through a database. Medical records were reviewed for presence of a colonoscopy report. Two hundred and sixty-four subjects were identified who had both a breath methane level measurement and a colonoscopy result. Additional demographic and clinical data were obtained with chart review.
Mean breath methane levels were higher in subjects with diverticulosis compared to those without diverticulosis (7.89 vs. 4.94 ppm, p = 0.04). Methane producers (defined as those with baseline fasting breath methane level >5 ppm) were more frequent among subjects with diverticulosis compared to those without diverticulosis (50.9 vs. 34 %, p = 0.0025). When adjusted for confounders, breath methane levels and age were the two independent predictors of diverticulosis on colonoscopy with logistic regression modeling.
Methanogenesis is associated with the presence of diverticulosis. Further studies are needed to confirm our findings and prospectively evaluate a possible etiological role of methanogenesis and methanogenic archaea in diverticulosis.
在美国及整个西方世界，憩室病及其并发症是重要的医疗问题。虽然憩室病发生的机制已得到部分探索，但很少有研究探讨人类结肠气体（如甲烷）与憩室病之间的关系。
本研究旨在证明产甲烷古菌与憩室病发展之间存在显著关系。
通过数据库对2003年至2010年在拉什大学医学中心连续接受氢呼气试验的受试者进行回顾性识别。查阅病历以确定是否有结肠镜检查报告。识别出264名同时有呼气甲烷水平测量值和结肠镜检查结果的受试者。通过查阅图表获取其他人口统计学和临床数据。
与无憩室病的受试者相比，憩室病受试者的平均呼气甲烷水平更高（7.89 vs. 4.94 ppm，p = 0.04）。与无憩室病的受试者相比，憩室病受试者中甲烷产生者（定义为基线空腹呼气甲烷水平>5 ppm者）更为常见（50.9% vs. 34%，p = 0.0025）。在逻辑回归模型中，调整混杂因素后，呼气甲烷水平和年龄是结肠镜检查中憩室病的两个独立预测因素。
甲烷生成与憩室病的存在有关。需要进一步研究来证实我们的发现，并前瞻性评估甲烷生成和产甲烷古菌在憩室病中可能的病因学作用。
