Honsawek Sittisak, Udomsinprasert Wanvisa, Vejchapipat Paisarn, Chongsrisawat Voranush, Phavichitr Nopaorn, Poovorawan Yong
Department of Biochemistry .
Biomarkers. 2015 Mar;20(2):157-61. doi: 10.3109/1354750X.2015.1045032. Epub 2015 May 18.
To analyze serum periostin and liver stiffness in postoperative biliary atresia (BA).
A total of 60 BA patients and 14 controls were enrolled. Serum periostin levels were analyzed by ELISA. Liver stiffness measurement was determined by transient elastography.
Biliary atresia patients had significantly higher periostin and liver stiffness values than controls. Serum periostin levels were remarkably increased in BA patients with jaundice compared to those without jaundice. Moreover, serum periostin was correlated with liver stiffness.
Serum periostin was associated with liver stiffness in BA. Thus, serum periostin has potential as a parameter reflecting the severity in BA.
分析术后胆道闭锁（BA）患者的血清骨膜蛋白和肝脏硬度。
共纳入60例BA患者和14例对照。采用酶联免疫吸附测定法（ELISA）分析血清骨膜蛋白水平。通过瞬时弹性成像测定肝脏硬度。
胆道闭锁患者的骨膜蛋白和肝脏硬度值显著高于对照组。与无黄疸的BA患者相比，有黄疸的BA患者血清骨膜蛋白水平显著升高。此外，血清骨膜蛋白与肝脏硬度相关。
BA患者血清骨膜蛋白与肝脏硬度相关。因此，血清骨膜蛋白有潜力作为反映BA严重程度的一个参数。
