Weng Kuo-Feng, Hsieh Po-Ting, Huang Hsing-I, Shih Shin-Ru
Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Microbes Infect. 2015 Aug;17(8):557-63. doi: 10.1016/j.micinf.2015.04.005. Epub 2015 May 14.
The role of virus-derived small RNAs (vsRNAs) has been identified as an antiviral mechanism in plants, arthropods, and nematodes. Although mammalian DNA viruses have been observed to encode functional miRNAs, whether RNA virus infection generates functional vsRNAs remains under discussion. This article reviews the most recent reports regarding pathways for generating vsRNAs and the identified vsRNA activity in mammalian cells infected with RNA viruses. We also discuss several hypotheses regarding the roles of mammalian vsRNAs and comment on the potential directions for this research field.
病毒衍生的小RNA（vsRNAs）的作用已被确定为植物、节肢动物和线虫中的一种抗病毒机制。尽管已观察到哺乳动物DNA病毒可编码功能性miRNA，但RNA病毒感染是否会产生功能性vsRNAs仍在讨论之中。本文综述了关于产生vsRNAs的途径以及在感染RNA病毒的哺乳动物细胞中已确定的vsRNA活性的最新报道。我们还讨论了关于哺乳动物vsRNAs作用的几种假说，并对该研究领域的潜在方向进行了评论。
