Department of Entomology, Iowa State University, Ames, IA 50011, USA.
J Invertebr Pathol. 2013 Oct;114(2):186-95. doi: 10.1016/j.jip.2013.07.006. Epub 2013 Aug 8.
The recently characterized small RNAs provide a new paradigm for physiological studies. These molecules have been shown to be integral players in processes as diverse as development and innate immunity against bacteria and viruses in eukaryotes. Several of the well-characterized small RNAs including small interfering RNAs, microRNAs and PIWI-interacting RNAs are emerging as important players in mediating arthropod host-virus interactions. Understanding the role of small RNAs in arthropod host-virus molecular interactions will facilitate manipulation of these pathways for both management of arthropod pests of agricultural and medical importance, and for protection of beneficial arthropods such as honey bees and shrimp. This review highlights recent research on the role of small RNAs in arthropod host-virus interactions with reference to other host-pathogen systems.
最近被描述的小 RNA 为生理研究提供了一个新的范例。这些分子已被证明是真核生物中发育和先天免疫抵抗细菌和病毒等多种过程的重要参与者。几种特征明确的小 RNA，包括小干扰 RNA、microRNA 和 PIWI 相互作用 RNA，正在成为介导节肢动物宿主-病毒相互作用的重要参与者。了解小 RNA 在节肢动物宿主-病毒分子相互作用中的作用将有助于操纵这些途径，以管理农业和医学上重要的节肢动物害虫，并保护有益的节肢动物，如蜜蜂和虾。本综述重点介绍了小 RNA 在节肢动物宿主-病毒相互作用中的作用的最新研究，同时也参考了其他宿主-病原体系统。
