Roy S, Colmant C, Cordier A-G, Sénat M-V
Hôpital Bicêtre, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France.
Hôpital Bicêtre, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France.
J Gynecol Obstet Biol Reprod (Paris). 2016 May;45(5):478-83. doi: 10.1016/j.jgyn.2015.04.012. Epub 2015 May 13.
Posterior urethral valves (PUV) are the most common cause of renal impairment in boys during early childhood. The aim of this study was to evaluate the value of ultrasound (US) criteria currently used to diagnose PUV.
From 2009 to 2012, 31 patients were referred to the Bicêtre Hospital after detection of fetal bilateral hydronephrosis in male fetus. The ultrasound criteria were bladder dilation, thick-walled bladder, urethral dilation ("keyhole sign"), and amniotic fluid volume. Patients were divided in two groups: suspected or not to have PUV.
US diagnosis of PUV was done in 18 fetuses and confirmed in 14 new borns, one of them without prenatal diagnosis. Sensitivity and specificity of US scan were 92.8 and 66.7%. The likelihood ratio (LHR) was 4.8 for a thick-walled bladder, 4.2 for oligohydramnios, 3.6 for the "keyhole sign", 2.4 for bladder dilation and 1.6 for ureteral dilation. The first four signs were combined in four fetuses, all of them with PUV.
US scan is a very sensitive exam for the diagnosis of PUV but with a low specificity. A thick-walled bladder seems to have a better diagnostic performance than the "keyhole sign".
后尿道瓣膜(PUV)是幼儿期男孩肾功能损害的最常见原因。本研究的目的是评估目前用于诊断PUV的超声(US)标准的价值。
2009年至2012年,31例男性胎儿在检测到双侧肾积水后被转诊至比塞特尔医院。超声标准包括膀胱扩张、膀胱壁增厚、尿道扩张(“钥匙孔征”)和羊水量。患者分为两组:疑似患有或未患有PUV。
18例胎儿经超声诊断为PUV,14例新生儿确诊,其中1例产前未诊断。超声扫描的敏感性和特异性分别为92.8%和66.7%。膀胱壁增厚的似然比(LHR)为4.8,羊水过少为4.2,“钥匙孔征”为3.6,膀胱扩张为2.4,输尿管扩张为1.6。四个胎儿同时出现前四个体征,均患有PUV。
超声扫描对PUV的诊断非常敏感,但特异性较低。膀胱壁增厚似乎比“钥匙孔征”具有更好的诊断性能。