布鲁氏菌病患儿的血液学检查结果

Hematological findings in children with brucellosis.

作者信息

Aypak Adalet, Aypak Cenk, Bayram Yasemin

机构信息

Department of Infectious Diseases and Clinical Microbiology.

Department of Family Medicine, Van Gevaş State Hospital.

出版信息

Pediatr Int. 2015 Dec;57(6):1108-11. doi: 10.1111/ped.12688. Epub 2015 Oct 20.

DOI:10.1111/ped.12688

PMID:25980959

Abstract

BACKGROUND

Brucellosis produces a variety of non-specific hematological abnormalities. The aim of the present study was to evaluate the hematological findings in childhood brucellosis.

METHODS

Medical records of children with brucellosis admitted to a tertiary hospital in a 1 year period, were analyzed retrospectively.

RESULTS

Sixty-nine patients (mean age, 14.5 ± 3.3 years) were diagnosed with brucellosis. The most common hematological finding was thrombocytopenia (n = 11, 15.9%). Thrombocytosis was detected in five patients (7.3%), leukopenia in four (5.8%), anemia in three (4.3%), and bicytopenia in three (4.3%). None of the patients had pancytopenia. Blood culture was positive for Brucella spp. in 41 patients (59.4%). Among those patients with positive blood culture, six (14.6%) had serum agglutination test titer ≤1/80. Platelet (PLT) count was significantly lower in the bacteremia-positive group. The OR (95%CI) of bacteremia for PLT cut-off 200,000/mm(3) was 0.148 (95%CI: 0.031-0.718) and relative risk was 1.718 (95%CI: 1.244-2.372; P = 0.010).

CONCLUSIONS

Brucellosis should be kept in mind in the differential diagnosis of isolated thrombocytopenia in pediatric patients from endemic areas.

摘要

背景

布鲁氏菌病会导致多种非特异性血液学异常。本研究旨在评估儿童布鲁氏菌病的血液学表现。

方法

回顾性分析一家三级医院在1年期间收治的布鲁氏菌病患儿的病历。

结果

69例患者（平均年龄14.5±3.3岁）被诊断为布鲁氏菌病。最常见的血液学表现是血小板减少（n = 11，15.9%）。5例患者（7.3%）检测到血小板增多，4例（5.8%）白细胞减少，3例（4.3%）贫血，3例（4.3%）全血细胞减少。所有患者均无全血细胞减少。41例患者（59.4%）血培养布鲁氏菌属阳性。在血培养阳性的患者中，6例（14.6%）血清凝集试验滴度≤1/80。菌血症阳性组的血小板（PLT）计数显著较低。血小板计数临界值为200,000/mm³时，菌血症的OR（95%CI）为0.148（95%CI：0.031 - 0.718），相对危险度为1.718（95%CI：1.244 - 2.372；P = 0.010）。