Youssef Nour, Youssef Yolla, Noun Dolly, Abboud Miguel, Dbaibo Ghassan
Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Division of Pediatric Infectious Diseases, Department of Pediatrics and Adolescent Medicine, Lebanon.
IDCases. 2022 Jun 15;29:e01531. doi: 10.1016/j.idcr.2022.e01531. eCollection 2022.
Brucellosis is one of the most prevalent zoonotic infections in the Middle East. The disease may present with a range of symptoms from a simple febrile illness to severe invasive infections affecting different organ systems (meningitis, osteomyelitis). In this paper we present an eleven-year-old girl who was diagnosed with "idiopathic bone marrow aplasia" and planned for hematopoietic stem cell transplant (HSCT), when pre-transplant work-up showed high brucella titers. The patient was started on doxycycline, rifampin and gentamicin initially, with discontinuation of the latter 3 weeks into therapy. She recovered completely after 8 months of treatment.
布鲁氏菌病是中东地区最常见的人畜共患感染病之一。该疾病的症状表现多样，从简单的发热性疾病到影响不同器官系统的严重侵袭性感染（脑膜炎、骨髓炎）。在本文中，我们介绍了一名11岁女孩，她被诊断为“特发性骨髓再生障碍”，并计划进行造血干细胞移植（HSCT），然而移植前检查显示布鲁氏菌滴度很高。患者最初开始使用强力霉素、利福平和庆大霉素治疗，治疗3周后停用庆大霉素。经过8个月的治疗，她完全康复。
