Althen H, Huotilainen M, Grimm S, Escera C
Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Catalonia, Spain; Cognitive Neuroscience Research Group, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalonia, Spain.
Finnish Institute of Occupational Health, Helsinki, Finland; Cognitive Brain Research Unit, Institute for Behavioural Sciences, University of Helsinki, Finland.
Clin Neurophysiol. 2016 Jan;127(1):388-396. doi: 10.1016/j.clinph.2015.04.058. Epub 2015 Apr 24.
This study aimed to test single and double deviance-related modulations of the middle latency response (MLR) and the applicability of the optimum-2 multi-feature paradigm.
The MLR and the MMN to frequency, intensity and double-feature deviants of an optimum-2 multi-feature paradigm and the MMN to double-feature deviants of an oddball paradigm were recorded in young adults.
Double deviants elicited significant enhancements of the Nb and Pb MLR waves compared with the waves elicited by standard stimuli. These enhancements equalled approximately the sum of the numerical amplitude differences elicited by the single deviants. In contrast, the MMN to double deviants did not show such additivity. MMNs elicited by double deviants of the multi-feature and the oddball paradigm showed no significant difference in amplitude or latency.
The optimum-2 multi-feature paradigm is suitable for recording double deviance-related modulations of the MLR. Interspersed intensity and frequency deviants in the standard trace of the optimum-2 condition multi-feature paradigm did not weaken the double MMN.
The optimum-2 multi-feature paradigm could be especially beneficial for clinical studies on early deviance-related modulations in the MLR, due to its optimized utilization of the recording time.
本研究旨在测试中潜伏期反应（MLR）与单偏差和双偏差相关的调制，以及最佳-2多特征范式的适用性。
在年轻成年人中记录最佳-2多特征范式中MLR以及对频率、强度和双特征偏差的失匹配负波（MMN），还有奇偶数范式中对双特征偏差的MMN。
与标准刺激引发的波相比，双偏差引发了Nb和Pb MLR波的显著增强。这些增强大致等于单偏差引发的数值幅度差异之和。相比之下，对双偏差的MMN并未表现出这种可加性。多特征范式和奇偶数范式的双偏差引发的MMN在幅度或潜伏期上没有显著差异。
最佳-2多特征范式适用于记录与双偏差相关的MLR调制。在最佳-2条件多特征范式的标准序列中穿插强度和频率偏差不会削弱双MMN。
由于最佳-2多特征范式对记录时间的优化利用，它可能对MLR中早期偏差相关调制的临床研究特别有益。
