Martínez-Ramos Cristina, Gómez-Pinedo Ulises, Esparza Maria Angeles Garcia, Soria José Miguel, Barcia Juan A, Monleón Pradas Manuel
Centro de Biomateriales, Universitat Politècnica de València, P. O. Box 22012, E-46071 València, Spain.
Servicio de Neurocirugía, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), C/ Profesor Martín Lagos, S/N, 28040 Madrid, Spain; Red de Terapia Celular (TerCel), Instituto Nacional de Salud Carlos III, Spain.
Neurosci Lett. 2015 Jun 26;598:96-101. doi: 10.1016/j.neulet.2015.05.021. Epub 2015 May 14.
The objective of the present study was to evaluate the biocompatibility and cell hosting ability of a copolymer scaffold based on ethyl acrylate (EA) and hydroxyl ethyl acrylate (HEA) in vivo after an experimental brain injury. Wistar rats were subjected to cryogenic traumatic brain injury. We evaluated the tissue response to the implanted materials after 8 weeks. The materials were implanted devoid of cells; they provoked a minimal scar response by the host tissue and permitted the invasion of neurons and glia inside them. We also found new blood vessels surrounding and inside the implant. Thus, the copolymer scaffold proves to offer a suitable environment producing a cellular network potentially useful in brain repair after brain injury.
