Smith Roger J, Santamaria John D, Faraone Espedito E, Holmes Jennifer A, Reid David A, Tobin Antony E
Department of Critical Care Medicine, St Vincent's Hospital, Melbourne, Australia.
J Crit Care. 2015 Aug;30(4):692-7. doi: 10.1016/j.jcrc.2015.04.004. Epub 2015 Apr 16.
The purpose of this study is to compare cases of rapid response team (RRT) review for early deterioration (<48 hours after admission), intermediate deterioration (48 to <168 hours after admission), late deterioration (≥168 hours after admission), and cardiac arrest and to determine the association between duration of hospitalization before RRT review and mortality.
This is a retrospective cohort study of RRT cases from a single hospital over 5 years (2009-2013) using administrative data and data for the first RRT attendance of each hospital episode.
Of 2843 RRT cases, 971 (34.2%) were early deterioration, 917 (32.3%) intermediate, 775 (27.3%) late, and 180 (6.3%) cardiac arrest. Compared with early deterioration patients, late deterioration patients were older (median, 71 vs 69 years; P = .005), had a higher Charlson comorbidity index (median, 2 vs 1; P < .001), more often had RRT review for respiratory distress (32.5% vs 23.5%; P < .001), more often received RRT-initiated not for resuscitation orders (8.4% vs 3.9%; P < .001), less often were discharged directly home (27.9% vs 58.4%; P < .001), and more often died in hospital (30.6% vs 12.8%; P < .001). Compared with early deterioration and adjusted for confounders, the odds ratio of death in hospital for late deterioration was 2.36 (1.81-3.08; P < .001).
Late deterioration is frequently encountered by the RRT and, compared with early deterioration, is associated with greater clinical complexity and a worse hospital outcome.
本研究旨在比较快速反应团队(RRT)对早期病情恶化(入院后<48小时)、中期病情恶化(入院后48至<168小时)、晚期病情恶化(入院后≥168小时)及心脏骤停情况的审查病例,并确定RRT审查前住院时间与死亡率之间的关联。
这是一项回顾性队列研究,利用行政数据及各次住院期间首次RRT出诊数据,对一家医院5年(2009 - 2013年)内的RRT病例进行研究。
在2843例RRT病例中,971例(34.2%)为早期病情恶化,917例(32.3%)为中期,775例(27.3%)为晚期,180例(6.3%)为心脏骤停。与早期病情恶化患者相比,晚期病情恶化患者年龄更大(中位数,71岁对69岁;P = 0.005),Charlson合并症指数更高(中位数,2对1;P < 0.001),因呼吸窘迫接受RRT审查的频率更高(32.5%对23.5%;P < 0.001),因非复苏医嘱启动RRT的频率更高(8.4%对3.9%;P < 0.001),直接出院回家的频率更低(27.9%对58.4%;P < 0.001),且院内死亡频率更高(30.6%对12.8%;P < 0.001)。与早期病情恶化相比并校正混杂因素后,晚期病情恶化患者院内死亡的比值比为2.36(1.81 - 3.08;P < 0.001)。
RRT经常遇到晚期病情恶化情况,与早期病情恶化相比,其临床复杂性更高,医院结局更差。