非细胞毒性的脱唾液酸GM1阳性细胞具有抗转移活性。
Non-cytotoxic asialo-GM1-positive cells exert antimetastatic activity.
作者信息
Strzadala L, Rak I, Ziolo E, Paprocka M, Radzikowski C, Den Otter W
机构信息
Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
出版信息
Cancer Immunol Immunother. 1989;30(1):51-6. doi: 10.1007/BF01665030.
Metastasis can be inhibited by asialo-GM1-positive spleen cells, and in this paper we show that there are two such spleen cell populations. One population is adherent and non-cytotoxic to YAC cells, whereas the other population is non-adherent and cytotoxic to YAC cells. Both cell populations exert an antimetastatic activity in cyclophosphamide-treated mice that are inoculated with LL2 Lewis lung carcinoma cells. We conclude that the antimetastatic activity is not only exerted by cytotoxic asialo-GM1-positive cells (apparently natural killer cells), but also by adherent, non-cytotoxic asialo-GM1+, Thy1.2-, IgG- cells. This means that the latter exert their antimetastatic activity by a non-cytotoxic mechanism.
去唾液酸GM1阳性脾细胞可抑制转移，在本文中我们表明存在两种这样的脾细胞群体。一种群体对YAC细胞具有粘附性且无细胞毒性，而另一种群体对YAC细胞无粘附性且具有细胞毒性。在接种了LL2 Lewis肺癌细胞的环磷酰胺处理小鼠中，这两种细胞群体均发挥抗转移活性。我们得出结论，抗转移活性不仅由具有细胞毒性的去唾液酸GM1阳性细胞（显然是自然杀伤细胞）发挥，还由粘附性、无细胞毒性的去唾液酸GM1+、Thy1.2-、IgG-细胞发挥。这意味着后者通过非细胞毒性机制发挥其抗转移活性。
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