Merluzzi V J
Cell Immunol. 1985 Oct 1;95(1):95-104. doi: 10.1016/0008-8749(85)90298-9.
Precursors and effectors of murine lymphokine-activated killer cells, natural killer cells, and cytotoxic T lymphocytes are compared. Natural killer cells are resistant to gamma-irradiation (1000 R) whereas precursors of lymphokine-activated killer cells and cytotoxic T lymphocytes are sensitive. Lower doses of gamma-irradiation (500 R) remove precursors for cytotoxic T lymphocytes but not lymphokine-activated killer cells. In addition, lymphokine-activated killer cells are regenerated before classical CTL after sublethal doses of gamma-irradiation. Natural killer cells are resistant to anti-Thy 1 and C' and anti-thymocyte serum, but sensitive to anti-asialo GM1 and complement. Precursors of cytotoxic T lymphocytes are sensitive to anti-Thy 1 and complement and anti-thymocyte serum, but are resistant to anti-asialo GM1 and complement. Precursors of lymphokine-activated killer cells are partially sensitive to anti-Thy 1 and complement and anti-thymocyte serum, but are resistant to anti-asialo GM1 and complement. Effector cells of cytotoxic T lymphocytes are sensitive to anti-Thy 1 and complement and resistant to anti-asialo GM1 and complement. Lymphokine-activated killer cell effectors are sensitive to anti-asialo GM1 and complement at 24 hr after activation. These effectors are more closely aligned with classical natural killer effectors. Lymphokine-activated killer effectors, 7 days after activation, are resistant to anti-asialo GM1 and complement and sensitive to anti-Thy 1 and complement. Relationships and differences among these cytotoxic subsets are discussed.
对小鼠淋巴因子激活的杀伤细胞、自然杀伤细胞和细胞毒性T淋巴细胞的前体细胞和效应细胞进行了比较。自然杀伤细胞对γ射线照射（1000拉德）具有抗性，而淋巴因子激活的杀伤细胞和细胞毒性T淋巴细胞的前体细胞则敏感。较低剂量的γ射线照射（500拉德）可去除细胞毒性T淋巴细胞的前体细胞，但不会去除淋巴因子激活的杀伤细胞的前体细胞。此外，在亚致死剂量的γ射线照射后，淋巴因子激活的杀伤细胞比经典的细胞毒性T淋巴细胞更早再生。自然杀伤细胞对抗Thy 1和补体以及抗胸腺细胞血清具有抗性，但对抗唾液酸GM1和补体敏感。细胞毒性T淋巴细胞的前体细胞对抗Thy 1和补体以及抗胸腺细胞血清敏感，但对抗唾液酸GM1和补体具有抗性。淋巴因子激活的杀伤细胞的前体细胞对抗Thy 1和补体以及抗胸腺细胞血清部分敏感，但对抗唾液酸GM1和补体具有抗性。细胞毒性T淋巴细胞的效应细胞对抗Thy 1和补体敏感，对抗唾液酸GM1和补体具有抗性。淋巴因子激活的杀伤细胞效应细胞在激活后24小时对抗唾液酸GM1和补体敏感。这些效应细胞与经典的自然杀伤效应细胞更为相似。激活7天后的淋巴因子激活的杀伤细胞效应细胞对抗唾液酸GM1和补体具有抗性，对抗Thy 1和补体敏感。讨论了这些细胞毒性亚群之间的关系和差异。
