Hazemoto N, Ishizaka S, Haga M, Kato Y, Kurosawa S, Kamo N, Kobatake Y
Chem Pharm Bull (Tokyo). 1989 Aug;37(8):2153-4. doi: 10.1248/cpb.37.2153.
Ion-selective electrodes (ISEs) responsive to the antitussives dextromethorphan and dimemorfan were constructed by the fixation of an ion-exchanger, ammonium tetraphenylborate, on a Millipore membrane by means of a plasma-polymerization technique. The electrodes showed a Nernstian response over the range of 10(-5)-10(-2) M dextromethorphan and dimemorphan, and the working pH range was 5-7. The interference from common cations such as Na+, K+ and Ca2+ was negligible but some organic cations interfered weakly. The electrodes were applied successfully for the determination of the drugs in pharmaceutical preparations.
通过等离子体聚合技术将离子交换剂四苯基硼酸铵固定在微孔膜上，构建了对镇咳药右美沙芬和二甲啡烷有响应的离子选择电极（ISE）。这些电极在10⁻⁵ - 10⁻² M的右美沙芬和二甲啡烷范围内呈现能斯特响应，工作pH范围为5 - 7。常见阳离子如Na⁺、K⁺和Ca²⁺的干扰可忽略不计，但一些有机阳离子有微弱干扰。这些电极已成功应用于药物制剂中药物的测定。
