血浆中右啡烷的测定及氢溴酸右美沙芬在人体中的生物利用度评估。
Determination of dextrorphan in plasma and evaluation of bioavailability of dextromethorphan hydrobromide in humans.
作者信息
Ramachander G, Williams F D, Emele J F
出版信息
J Pharm Sci. 1977 Jul;66(7):1047-8. doi: 10.1002/jps.2600660740.
PMID:886444
Abstract
A method is described for the estimation of dextrorphan, a metabolite of dextromethorphan, in plasma. The bioavailability of dextromethorphan hydrobromide after 30 mg po, as measured by the concentration of total (free and conjugated) dextrorphan in the plasma, was determined in six human volunteers with this procedure.
摘要
本文描述了一种测定血浆中右美沙芬代谢物右啡烷的方法。采用该方法，在6名人类志愿者中测定了口服30毫克氢溴酸右美沙芬后，通过血浆中总（游离和结合）右啡烷浓度测得的氢溴酸右美沙芬的生物利用度。
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