Marín-Jiménez Ignacio, Gisbert Javier P, Pérez-Calle José L, García-Sánchez Valle, Tabernero Susana, García-Vicuña Rosario, Romero Cristina, Juliá Berta, Vanaclocha Francisco, Cea-Calvo Luis
Departamento de Gastroenterología, Hospital Gregorio Marañón, Madrid, España.
Departamento de Gastroenterología, Hospital de La Princesa, IP y CIBERehd, Madrid, España.
Gastroenterol Hepatol. 2015 Dec;38(10):569-74. doi: 10.1016/j.gastrohep.2015.04.003. Epub 2015 May 14.
To describe the 2-year incidence of new immune-mediated inflammatory diseases (spondylarthritis, uveitis, psoriasis) in the cohort of patients with inflammatory bowel disease (IBD) included in the AQUILES study.
Over a 2-year period, 341 patients with IBD (53% women, mean age 40 years) diagnosed with Crohn's disease (60.5%), ulcerative colitis (38.1%) and indeterminate colitis (1.4%) were followed up. New diagnoses made during follow-up were based on reports of the corresponding specialists (rheumatologists, ophthalmologists, and dermatologists).
A total of 22 new diagnoses of immune-mediated inflammatory diseases were established in 21 patients (cumulative incidence of 6.5%, 95% confidence interval [CI] 3.7-9.2, incidence rate of 26 cases per 10,000 patient-years). Most diagnoses were new cases of spondylarthritis (n=15). The cumulative incidence of new diagnoses of immune-mediated inflammatory diseases was similar in patients with Crohn's disease (5.8%, 95% CI 3.4-9.9) and in patients with ulcerative colitis (7.7%, 95% CI 4.2-13.6). On multivariate analysis, the incidence of new immune-mediated inflammatory diseases was significantly associated with a family history of IBD (odds ratio=3.6, 95% CI 1.4-9.4) and the presence of extraintestinal manifestations of IBD (odds ratio=1.8, 95% CI .7-5.2).
In patients with IBD, the incidence of new immune-mediated inflammatory diseases at 2 years of follow-up was 6.5%. These diseases were more frequent in patients with extraintestinal manifestations of IBD and a family history of IBD.
描述纳入阿基里斯研究的炎症性肠病（IBD）患者队列中，新的免疫介导性炎症性疾病（脊柱关节炎、葡萄膜炎、银屑病）的2年发病率。
在2年期间，对341例IBD患者（53%为女性，平均年龄40岁）进行随访，这些患者被诊断为克罗恩病（60.5%）、溃疡性结肠炎（38.1%）和不确定性结肠炎（1.4%）。随访期间的新诊断基于相应专科医生（风湿病学家、眼科医生和皮肤科医生）的报告。
21例患者共确诊22例新的免疫介导性炎症性疾病（累积发病率为6.5%，95%置信区间[CI]为3.7 - 9.2，发病率为每10,000患者年26例）。大多数诊断为脊柱关节炎新病例（n = 15）。克罗恩病患者（5.8%，95% CI 3.4 - 9.9）和溃疡性结肠炎患者（7.7%，95% CI 4.2 - 13.6）中新诊断的免疫介导性炎症性疾病的累积发病率相似。多因素分析显示，新的免疫介导性炎症性疾病的发病率与IBD家族史（比值比 = 3.6，95% CI 1.4 - 9.4）和IBD肠外表现的存在（比值比 = 1.8，95% CI 0.7 - 5.2）显著相关。
在IBD患者中，随访2年时新的免疫介导性炎症性疾病的发病率为6.5%。这些疾病在有IBD肠外表现和IBD家族史的患者中更常见。
