Xu L F, Wang M, Zhao C L
Zhong Xi Yi Jie He Za Zhi. 1989 Aug;9(8):462-4, 451.
Effects of the gossypol on endometriosis in 12 cases of control were observed. The results showed that the gossypol administered orally was effective in endometriosis patients. The basal body temperature changed from biophase to monophase. Dysmenorrhea disappeared in 11/12 patients. Amenorrhea occurred in 10/12 patients and the ovarian endometrial cyst was shrinkable. Serum progesterone and estradiol were decreased after gossypol administration, but follicle-stimulating hormone and luteinizing hormone were increased evidently. Histochemical and cytochemical observations revealed that the activity of acid phosphate (ACP), nonspecific esterase (NSE) and alkaline phosphate (AKP) in both aberrant uterine endometrium and uterine endometrium in situ were decreased evidently. The above results suggest that the satisfactory therapeutic effect of gossypol on endometriosis may be due to not only the indirect but also the direct action on uterine endometrium.
观察了棉酚对12例对照子宫内膜异位症患者的影响。结果表明，口服棉酚对子宫内膜异位症患者有效。基础体温从双相变为单相。12例患者中有11例痛经消失。12例患者中有10例出现闭经，卵巢子宫内膜囊肿可缩小。服用棉酚后血清孕酮和雌二醇降低，但促卵泡激素和促黄体生成素明显升高。组织化学和细胞化学观察显示，异位子宫内膜和原位子宫内膜中酸性磷酸酶（ACP）、非特异性酯酶（NSE）和碱性磷酸酶（AKP）的活性均明显降低。上述结果表明，棉酚对子宫内膜异位症的良好治疗效果可能不仅归因于对子宫内膜的间接作用，还归因于直接作用。
