Zu P D, Sun Y T, Cheng J, Tian L, Dang M Y, Han M L
Am J Obstet Gynecol. 1984 Aug 1;149(7):780-7. doi: 10.1016/0002-9378(84)90122-4.
Gossypol treatment of endometriosis and uterine myomas in 15 cases was started with a daily dose of 20 mg of gossypol-acetic acid twice a day for 20 days as a loading dose, followed by 40 mg (20 mg twice weekly). A maintenance dose of 20 mg was given weekly. The total course of treatment lasted about 6 months. Light and electron microscopic examination of the endometrium was carried out before treatment and 2, 3, 4, and 6 months after gossypol treatment. After gossypol treatment three different characteristics of the endometrium were noted: (1) irregular secretory activity, (2) proliferative activity, and (3) atrophy. On electron microscopic examination it was shown that there were important changes of the organelles, indicating suppressed secretory activity. Based on the above results, the nature and significance of the ultrastructural changes of the endometrium induced by gossypol were analyzed and the possibility of developing a new field of research in female contraception with gossypol was considered.
用棉酚治疗15例子宫内膜异位症和子宫肌瘤，开始时每日剂量为棉酚醋酸酯20毫克，每日2次，共20天作为负荷剂量，随后为40毫克（每周2次，每次20毫克）。维持剂量为每周20毫克。治疗总疗程约6个月。在治疗前以及棉酚治疗后2、3、4和6个月对子宫内膜进行光镜和电镜检查。棉酚治疗后，观察到子宫内膜有三种不同特征：（1）不规则分泌活动，（2）增殖活动，（3）萎缩。电镜检查显示细胞器有重要变化，表明分泌活动受到抑制。根据上述结果，分析了棉酚诱导的子宫内膜超微结构变化的性质和意义，并考虑了开辟棉酚用于女性避孕新研究领域的可能性。
