Cimic Adela, Pastan Stephen O, Bijol Vanesa
Department of Pathology , Emory University Hospital.
Department of Medicine, Renal Division , Emory University School of Medicine , Atlanta, GA , USA.
NDT Plus. 2009 Aug;2(4):306-8. doi: 10.1093/ndtplus/sfp028. Epub 2009 Mar 4.
Membranous nephropathy (MN) is a common cause of nephrotic syndrome in older adults. The association of MN with neoplasia has been controversial, but several recent studies have shown increase incidence of cancer in patients with MN [1]. We report a case of a 49-year-old male with severe nephrotic syndrome and concomitant jejunal gastrointestinal stromal tumour (GIST). The combination of preoperative Imatinib mesylate chemotherapy and tumour excision was followed by complete resolution of proteinuria within 19 months, without specific treatment for MN. An association between MN and GIST has never previously been reported in the literature.
膜性肾病（MN）是老年患者肾病综合征的常见病因。MN与肿瘤形成之间的关联一直存在争议，但最近的几项研究表明，MN患者患癌症的发生率有所增加[1]。我们报告一例49岁男性，患有严重肾病综合征并伴有空肠胃肠道间质瘤（GIST）。术前甲磺酸伊马替尼化疗与肿瘤切除相结合，随后在19个月内蛋白尿完全消失，且未对MN进行特殊治疗。此前文献中从未报道过MN与GIST之间的关联。
