Department of Nephrology , Hospital Lucus Augusti , Lugo , Spain.
Department of Nephrology , Hospital Juan Cardona , Ferrol , Spain.
Clin Kidney J. 2012 Dec;5(6):562-5. doi: 10.1093/ckj/sfs144. Epub 2012 Nov 7.
Membranous nephropathy (MN) has been associated with several infectious, immunological and malignant conditions, but had only rarely been reported with malignant and other immune disorders in the same patient. We describe the case of a 56-year-old male with MN who was also diagnosed with a gastrointestinal stromal tumour (GIST), myasthenia gravis (MG) and thymic hyperplasia. Thus, we report here for the first time the coincidence of these conditions in the same patient. There was a recurrence of nephrotic syndrome without impairment of renal function 5 years after removal of the GIST (3 years after thymectomy). The possible basis for the relationship between these diseases is discussed, and some common genetic and immune physiopathological pathways are hypothesized.
膜性肾病（MN）与多种感染、免疫和恶性疾病有关，但在同一患者中同时出现恶性和其他免疫性疾病的情况很少见。我们描述了一例 56 岁男性 MN 患者，同时还被诊断为胃肠道间质瘤（GIST）、重症肌无力（MG）和胸腺增生。因此，我们首次报道了这些疾病在同一患者中的同时发生。在 GIST 切除后 5 年（胸腺切除后 3 年），肾病综合征复发，但肾功能无损害。讨论了这些疾病之间可能存在的关系的基础，并假设了一些共同的遗传和免疫病理生理途径。
