一例与抗H因子自身抗体相关的成人非典型溶血性尿毒症综合征经血浆置换、皮质类固醇和利妥昔单抗成功治疗的病例。
A case of adult atypical haemolytic uraemic syndrome related to anti-factor H autoantibodies successfully treated by plasma exchange, corticosteroids and rituximab.
作者信息
Lionet Arnaud, Provôt François, Glowacki François, Frémeaux-Bacchi Veronique, Hazzan Marc
机构信息
Department of Néphrology , Hospital Calmette , CHRU-Lille, Lille.
Department of Immunology , Höpital Europeen Georges Pompidou, Paris , France.
出版信息
NDT Plus. 2009 Dec;2(6):458-60. doi: 10.1093/ndtplus/sfp109. Epub 2009 Aug 18.
Complement factor H auto-antibodies (CFH-ab) are a rare cause (6-10%) of atypical haemolytic uraemic syndrome (aHUS). All observations previously described were retrospective and occurred in children or teenagers. We report the first case of aHUS associated with anti-CFH antibodies in an adult patient who was successfully treated by plasma exchange, corticosteroids and rituximab.
补体因子H自身抗体（CFH-ab）是非典型溶血性尿毒症综合征（aHUS）的罕见病因（6%-10%）。此前描述的所有观察结果均为回顾性研究，且发生在儿童或青少年中。我们报告了首例成年aHUS患者，其抗CFH抗体呈阳性，通过血浆置换、皮质类固醇和利妥昔单抗成功治愈。
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