• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一例与抗H因子自身抗体相关的成人非典型溶血性尿毒症综合征经血浆置换、皮质类固醇和利妥昔单抗成功治疗的病例。

A case of adult atypical haemolytic uraemic syndrome related to anti-factor H autoantibodies successfully treated by plasma exchange, corticosteroids and rituximab.

作者信息

Lionet Arnaud, Provôt François, Glowacki François, Frémeaux-Bacchi Veronique, Hazzan Marc

机构信息

Department of Néphrology , Hospital Calmette , CHRU-Lille, Lille.

Department of Immunology , Höpital Europeen Georges Pompidou, Paris , France.

出版信息

NDT Plus. 2009 Dec;2(6):458-60. doi: 10.1093/ndtplus/sfp109. Epub 2009 Aug 18.

DOI:10.1093/ndtplus/sfp109
PMID:25984036
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4421306/
Abstract

Complement factor H auto-antibodies (CFH-ab) are a rare cause (6-10%) of atypical haemolytic uraemic syndrome (aHUS). All observations previously described were retrospective and occurred in children or teenagers. We report the first case of aHUS associated with anti-CFH antibodies in an adult patient who was successfully treated by plasma exchange, corticosteroids and rituximab.

摘要

补体因子H自身抗体（CFH-ab）是非典型溶血性尿毒症综合征（aHUS）的罕见病因（6%-10%）。此前描述的所有观察结果均为回顾性研究，且发生在儿童或青少年中。我们报告了首例成年aHUS患者，其抗CFH抗体呈阳性，通过血浆置换、皮质类固醇和利妥昔单抗成功治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c21a/4421306/2b90a53df412/sfp109fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c21a/4421306/2b90a53df412/sfp109fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c21a/4421306/2b90a53df412/sfp109fig1.jpg

相似文献

1
A case of adult atypical haemolytic uraemic syndrome related to anti-factor H autoantibodies successfully treated by plasma exchange, corticosteroids and rituximab.一例与抗H因子自身抗体相关的成人非典型溶血性尿毒症综合征经血浆置换、皮质类固醇和利妥昔单抗成功治疗的病例。
NDT Plus. 2009 Dec;2(6):458-60. doi: 10.1093/ndtplus/sfp109. Epub 2009 Aug 18.
2
Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome.功能分析表明因子 H 自身抗体在非典型溶血尿毒症综合征中具有致病性作用。
Nephrol Dial Transplant. 2010 Jan;25(1):136-44. doi: 10.1093/ndt/gfp388. Epub 2009 Aug 7.
3
Rituximab to Abbreviate Plasma Exchange in Anti-CFH (Complement Factor H) Antibody Mediated Atypical HUS.利妥昔单抗可缩短抗CFH（补体因子H）抗体介导的非典型溶血尿毒综合征的血浆置换疗程。
Iran J Kidney Dis. 2019 Mar;13(2):134-138.
4
Indications of underdiagnosis of atypical haemolytic uraemic syndrome in a cohort referred to the Coagulation Unit in Malmo, Sweden, for analysis of ADAMTS13 2007-2012.2007年至2012年期间，在瑞典马尔默凝血科接受分析ADAMTS13的队列中，非典型溶血尿毒综合征诊断不足的指征。
Nephrology (Carlton). 2017 Jul;22(7):555-561. doi: 10.1111/nep.12818.
5
Consensus opinion on diagnosis and management of thrombotic microangiopathy in Australia and New Zealand.澳大利亚和新西兰关于血栓性微血管病诊断与管理的共识意见。
Nephrology (Carlton). 2018 Jun;23(6):507-517. doi: 10.1111/nep.13234.
6
Genetic disorders in complement (regulating) genes in patients with atypical haemolytic uraemic syndrome (aHUS).补体（调节）基因遗传缺陷与非典型溶血尿毒综合征（aHUS）。
Nephrol Dial Transplant. 2010 Jul;25(7):2195-202. doi: 10.1093/ndt/gfq010. Epub 2010 Jan 26.
7
Eculizumab in atypical haemolytic-uraemic syndrome allows cessation of plasma exchange and dialysis.依库珠单抗治疗非典型溶血尿毒综合征可停止血浆置换和透析。
Clin Kidney J. 2012 Feb;5(1):34-6. doi: 10.1093/ndtplus/sfr174. Epub 2012 Jan 30.
8
The role of complement in Streptococcus pneumoniae-associated haemolytic uraemic syndrome.补体在肺炎链球菌相关性溶血尿毒综合征中的作用。
Nephrol Dial Transplant. 2013 Sep;28(9):2237-45. doi: 10.1093/ndt/gft198. Epub 2013 Jun 19.
9
Severe left ventricular systolic dysfunction in a patient with a typical haemolytic-uraemic syndrome treated with rituximab-coincidence or cause?一名典型溶血尿毒综合征患者接受利妥昔单抗治疗后出现严重左心室收缩功能障碍——巧合还是因果关系？
NDT Plus. 2010 Jun;3(3):269-270. doi: 10.1093/ndtplus/sfq055. Epub 2010 Apr 9.
10
Haemolytic uraemic syndrome caused by factor H mutation: is single kidney transplantation under intensive plasmatherapy an option?补体因子 H 突变导致的溶血尿毒综合征：强化血浆置换治疗下单肾移植是否可行？
Nephrol Dial Transplant. 2009 Nov;24(11):3548-51. doi: 10.1093/ndt/gfp377. Epub 2009 Jul 25.

引用本文的文献

1
Anti-CFH-associated hemolytic uremic syndrome: do we still need plasma exchange?抗补体因子 H 相关性溶血尿毒症综合征：我们仍需要血浆置换吗？
Pediatr Nephrol. 2024 Nov;39(11):3263-3269. doi: 10.1007/s00467-024-06373-x. Epub 2024 Apr 17.
2
Poor allograft outcome in Indian patients with post-transplant C3 glomerulopathy.印度移植后C3肾小球病患者同种异体移植预后不佳。
Clin Kidney J. 2019 Nov 4;14(1):291-300. doi: 10.1093/ckj/sfz135. eCollection 2021 Jan.
3
Cobalamin c deficiency associated with antifactor h antibody-associated hemolytic uremic syndrome in a young adult.

本文引用的文献

1
Autoantibodies in haemolytic uraemic syndrome (HUS).溶血尿毒综合征（HUS）中的自身抗体。
Thromb Haemost. 2009 Feb;101(2):227-32.
2
Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome.补体C3突变易导致非典型溶血性尿毒症综合征的发生。
Blood. 2008 Dec 15;112(13):4948-52. doi: 10.1182/blood-2008-01-133702. Epub 2008 Sep 16.
3
Hemolytic uremic syndrome recurrence after renal transplantation.肾移植后溶血性尿毒症综合征复发
一名年轻成人中与抗因子H抗体相关的溶血性尿毒症综合征相关的钴胺素C缺乏症。
BMC Nephrol. 2020 Mar 12;21(1):96. doi: 10.1186/s12882-020-01748-2.
4
Case Series of 3 Patients Diagnosed With Atypical Hemolytic Uremic Syndrome Successfully Treated With Steroids, Plasmapheresis, and Rituximab.3例诊断为非典型溶血性尿毒症综合征患者经类固醇、血浆置换和利妥昔单抗成功治疗的病例系列
Can J Kidney Health Dis. 2017 Dec 31;5:2054358117747262. doi: 10.1177/2054358117747262. eCollection 2018.
5
Adjustment of Eculizumab Dosage Pattern in Patients with Atypical Hemolytic Uremic Syndrome with Suboptimal Response to Standard Treatment Pattern.对标准治疗方案反应欠佳的非典型溶血性尿毒症综合征患者依库珠单抗剂量模式的调整
Case Rep Nephrol. 2016;2016:7471082. doi: 10.1155/2016/7471082. Epub 2016 Nov 29.
6
A Case Report and Literature Review of Eculizumab Withdrawal in Atypical Hemolytic-Uremic Syndrome.一例非典型溶血尿毒综合征停用依库珠单抗的病例报告及文献综述
Am J Case Rep. 2016 Dec 15;17:950-956. doi: 10.12659/ajcr.899764.
7
An Update on the Use of Immunomodulators in Primary Immunodeficiencies.原发性免疫缺陷病中免疫调节剂的应用进展
Clin Rev Allergy Immunol. 2017 Apr;52(2):287-303. doi: 10.1007/s12016-016-8591-2.
8
Efficacy of rituximab and plasmapharesis in an adult patient with antifactor H autoantibody-associated hemolytic uremic syndrome: A case report and literature review.利妥昔单抗和血浆置换疗法对一名成年抗H因子自身抗体相关性溶血尿毒综合征患者的疗效：病例报告及文献综述
Medicine (Baltimore). 2016 Sep;95(39):e5007. doi: 10.1097/MD.0000000000005007.
9
Anti-complement-factor H-associated glomerulopathies.抗补体因子 H 相关肾小球病。
Nat Rev Nephrol. 2016 Sep;12(9):563-78. doi: 10.1038/nrneph.2016.99. Epub 2016 Jul 25.
10
Atypical Hemolytic Uremic Syndrome: Differential Diagnosis from TTP/HUS and Management.非典型溶血性尿毒症综合征：与血栓性血小板减少性紫癜/溶血性尿毒症综合征的鉴别诊断及管理
Turk J Haematol. 2014 Sep 5;31(3):216-25. doi: 10.4274/tjh.2013.0374.
Pediatr Transplant. 2008 Sep;12(6):619-29. doi: 10.1111/j.1399-3046.2008.00910.x. Epub 2008 May 10.
4
Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency.非典型溶血性尿毒症综合征中的H因子自身抗体与CFHR1/CFHR3缺乏相关。
Blood. 2008 Feb 1;111(3):1512-4. doi: 10.1182/blood-2007-09-109876. Epub 2007 Nov 15.
5
Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome.补体因子B的功能获得性突变与非典型溶血性尿毒症综合征相关。
Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):240-5. doi: 10.1073/pnas.0603420103. Epub 2006 Dec 20.
6
Anti-Factor H autoantibodies associated with atypical hemolytic uremic syndrome.与非典型溶血性尿毒症综合征相关的抗补体因子H自身抗体
J Am Soc Nephrol. 2005 Feb;16(2):555-63. doi: 10.1681/ASN.2004050380. Epub 2004 Dec 8.