Clissold Rhian, Bingham Coralie
Royal Devon and Exeter Hospital , Barrack Road, Wonford, Exeter, Devon EX2 5DW , UK.
NDT Plus. 2010 Oct;3(5):480-2. doi: 10.1093/ndtplus/sfq113. Epub 2010 Jun 17.
Toxoplasma gondii is a rare cause of infection in renal transplant recipients and usually occurs within 3 months of transplantation, this being the period of maximum immunosuppression. We report two cases of toxoplasmosis presenting several years after transplantation. One patient developed Toxoplasma retinitis 4 years after renal transplantation and lost peripheral vision in his affected eye. Another developed cerebral toxoplasmosis 6 years following his second renal transplant but did not survive despite treatment. These cases highlight the need for a high index of suspicion of toxoplasmosis as a potential diagnosis even during the later stages of the post-transplant period as survival is poor without early recognition and treatment.
弓形虫是肾移植受者感染的罕见病因，通常发生在移植后3个月内，这是免疫抑制最强的时期。我们报告了两例移植数年之后出现的弓形虫病病例。一名患者在肾移植4年后发生弓形虫性视网膜炎，患眼周边视力丧失。另一名患者在第二次肾移植6年后发生脑弓形虫病，尽管接受了治疗仍未存活。这些病例凸显了即使在移植后期也需要高度怀疑弓形虫病作为潜在诊断的必要性，因为如果不及早识别和治疗，预后很差。
