Department of Neurosurgery, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul 07061, Korea.
Department of Pathology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Korea.
Korean J Parasitol. 2022 Feb;60(1):35-38. doi: 10.3347/kjp.2022.60.1.35. Epub 2022 Feb 23.
Cerebral toxoplasmosis is often life-threatening in an immunocompromised patient due to delayed diagnosis and treatment. Several differential diagnoses could be possible only with preoperative brain images of cerebral toxoplasmosis which show multiple rim-enhancing lesions. Due to the rarity of cerebral toxoplasmosis cases in Korea, the diagnosis and treatment are often delayed. This paper concerns a male patient whose cerebral toxoplasmosis was activated 21 years post kidney transplantation. Brain open biopsy was decided to make an exact diagnosis. Cerebral toxoplasmosis was confirmed by immunohistochemistry and PCR analyses of the tissue samples. Although cerebral toxoplasmosis was under control with medication, the patient did not recover clinically and died due to sepsis and recurrent gastrointestinal bleeding.
脑弓形虫病在免疫功能低下的患者中常因诊断和治疗延误而危及生命。只有通过脑弓形虫病的术前脑影像才能明确诊断出多种边缘增强病变，这可能是其他一些不同的疾病。由于脑弓形虫病在韩国较为罕见，因此诊断和治疗常常会被延误。本文报告了一位男性患者，他在肾移植后 21 年出现脑弓形虫病激活。为了明确诊断，决定进行开颅活检。通过对组织样本进行免疫组织化学和 PCR 分析，证实了脑弓形虫病的诊断。尽管通过药物治疗控制了脑弓形虫病，但患者并未在临床上康复，最终因脓毒症和反复胃肠道出血而死亡。
