Karmonik Christof, Partovi Sasan, Rengier Fabian, Meredig Hagen, Farag Mina Berty, Müller-Eschner Matthias, Arif Rawa, Popov Aron-Frederik, Kauczor Hans-Ulrich, Karck Matthias, Ruhparwar Arjang
1 Magnetic Resonance Imaging Core, Houston Methodist Research Institute, Houston, Texas, USA ; 2 Department of Radiology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA ; 3 Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany ; 4 Department of Radiology E010, German Cancer Research Center (DKFZ), Heidelberg, Germany ; 5 Department of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany ; 6 Department of Cardiothoracic Transplantation and Mechanical Support, Royal Brompton and Harefield NHS Trust, Harefield Hospital, London, UK.
Cardiovasc Diagn Ther. 2015 Apr;5(2):160-5. doi: 10.3978/j.issn.2223-3652.2015.03.03.
Partial mechanical circulatory support represents a new concept for the treatment of advanced heart failure. The Circulite Synergy Micro Pump(®), where the inflow cannula is connected to the left atrium and the outflow cannula to the right subclavian artery, was one of the first devices to introduce this concept to the clinic. Using computational fluid dynamics (CFD) simulations, hemodynamics in the aortic tree was visualized and quantified from computed tomography angiographic (CTA) images in two patients. A realistic computational model was created by integrating flow information from the native heart and from the Circulite device. Diastolic flow augmentation in the descending aorta but competing/antagonizing flow patterns in the proximal innominate artery was observed. Velocity time curves in the ascending aorta correlated well with those in the left common carotid, the left subclavian and the descending aorta but poorly with the one in the innominate. Our results demonstrate that CFD may be useful in providing a better understanding of the main flow patterns in mechanical circulatory support devices.
部分机械循环支持是治疗晚期心力衰竭的一种新概念。Circulite Synergy微型泵（®），其流入插管连接到左心房，流出插管连接到右锁骨下动脉，是最早将这一概念引入临床的设备之一。利用计算流体动力学（CFD）模拟，在两名患者中从计算机断层血管造影（CTA）图像可视化并量化了主动脉树中的血流动力学。通过整合来自天然心脏和Circulite设备的血流信息创建了一个真实的计算模型。观察到降主动脉舒张期血流增加，但无名动脉近端存在竞争性/拮抗血流模式。升主动脉的速度时间曲线与左颈总动脉、左锁骨下动脉和降主动脉的曲线相关性良好，但与无名动脉的曲线相关性较差。我们的结果表明，CFD可能有助于更好地理解机械循环支持设备中的主要血流模式。
