Forge K, Vogel J, Ghavami C, Oehr P
Dtsch Z Mund Kiefer Gesichtschir. 1989 Jan-Feb;13(1):39-43.
In diagnosing and monitoring squamous cell carcinomas of the oral mucosa and the prolabium the carcinoembryonic antigen (CEA) is a frequently used tumor marker. In a pilot study six of these carcinomas with established pathological serum levels of CEA were clinically analyzed and immunohistochemically examined for the tumor antigens CEA and, in addition, TPA (tissue polypeptide antigen). Only in one case could a positive CEA reaction be found. In the same tumors TPA could not be demonstrated. It is concluded from these results that elevated CEA serum levels are no tumor specific reactions and that the use of this tumor marker is to be considered with criticism.
在诊断和监测口腔黏膜及唇前部的鳞状细胞癌时，癌胚抗原（CEA）是一种常用的肿瘤标志物。在一项初步研究中，对6例已确定血清CEA病理水平的此类癌症进行了临床分析，并对肿瘤抗原CEA以及组织多肽抗原（TPA）进行了免疫组化检查。仅在1例中发现了阳性CEA反应。在相同肿瘤中未检测到TPA。从这些结果可以得出结论，CEA血清水平升高并非肿瘤特异性反应，并且对这种肿瘤标志物的使用应持谨慎态度。
