Björklund V, Björklund B
Cancer Detect Prev. 1983;6(1-2):193-8.
The presence of tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA) in serial sections of 44 breast carcinomas, one case of neurofibrosarcoma, and one case of fibroadenoma was demonstrated by immunocytochemistry using the indirect peroxidase technique. The neurofibrosarcoma was negative for TPA and CEA. All 44 specimens of breast cancer were positive for TPA and/or CEA. In 18 cases the staining was strongly positive for TPA and CEA. The overall concordance of staining was 43%. TPA was more prominent than CEA in 52% of the tumors while CEA was more prominent in 7%. This is in relative agreement with the values for TPA and CEA in serum from patients with breast cancer, where TPA was higher than CEA in 41% and CEA higher than TPA in 9%. The finding of a difference between and within tumors indicated that TPA and CEA may be synthesized during partly different phases of the proliferative cycle. Assay of TPA and CEA in cytological specimens and in serum should be of clinical interest.
采用间接过氧化物酶技术，通过免疫细胞化学方法在44例乳腺癌、1例神经纤维肉瘤和1例纤维腺瘤的连续切片中检测组织多肽抗原（TPA）和癌胚抗原（CEA）。神经纤维肉瘤的TPA和CEA呈阴性。44例乳腺癌标本的TPA和/或CEA均呈阳性。18例染色TPA和CEA呈强阳性。染色的总体一致性为43%。52%的肿瘤中TPA比CEA更显著，而7%的肿瘤中CEA更显著。这与乳腺癌患者血清中TPA和CEA的值相对一致，其中41%的患者TPA高于CEA，9%的患者CEA高于TPA。肿瘤之间和肿瘤内部存在差异的结果表明，TPA和CEA可能在增殖周期的部分不同阶段合成。在细胞学标本和血清中检测TPA和CEA应具有临床意义。
