因心力衰竭住院患者中，可溶性生长刺激表达基因2蛋白（sST2）和半乳糖凝集素-3相对于肾功能对死亡的预后价值。
Prognostic value of sST2 and galectin-3 for death relative to renal function in patients hospitalized for heart failure.
作者信息
Zhang Rongcheng, Zhang Yuhui, An Tao, Guo Xiao, Yin Shijie, Wang Yunhong, Januzzi James L, Cappola Thomas P, Zhang Jian
机构信息
2Division of Cardiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.
3Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104, USA.
出版信息
Biomark Med. 2015;9(5):433-41. doi: 10.2217/bmm.15.12.
AIM
To evaluate the associations of soluble ST2 (sST2) and galectin-3 with death relative to renal function in patients with heart failure (HF).
METHODS
Eleven-hundred-and-sixty-one patients hospitalized for HF with 1-year follow up were enrolled for biomarkers analysis.
RESULTS
Patients were divided into two groups based on eGFR of either > or ≤60 ml/min/1.73 m(2). sST2 was independently associated with death in both categories of renal function, while galectin-3 lost this significance after addition of NT-proBNP to the model of patients with eGFR ≤60 ml/min/1.73 m(2).
CONCLUSION
In patients with HF, sST2 improved prediction for death beyond risk factors without being influenced by renal function, however, the prognostic value of galectin-3 is less clear below an eGFR of 60 ml/min/1.73 m(2).
目的
评估可溶性ST2（sST2）和半乳糖凝集素-3与心力衰竭（HF）患者肾功能相关死亡的关联。
方法
纳入1161例因HF住院且随访1年的患者进行生物标志物分析。
结果
根据估算肾小球滤过率（eGFR）>或≤60 ml/min/1.73 m²将患者分为两组。在两类肾功能患者中，sST2均与死亡独立相关，而在eGFR≤60 ml/min/1.73 m²患者模型中加入N末端B型利钠肽原（NT-proBNP）后，半乳糖凝集素-3失去了这种显著性。
结论
在HF患者中，sST2可改善对死亡的预测，不受肾功能影响且超越危险因素，然而，在eGFR<60 ml/min/1.73 m²时，半乳糖凝集素-3的预后价值尚不清楚。
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