半乳糖凝集素-3 和可溶性 ST2 用于慢性心力衰竭的生物学变异：对检测结果解读的影响。
Biological variation of galectin-3 and soluble ST2 for chronic heart failure: implication on interpretation of test results.
机构信息
Clinical Chemistry Laboratory, Department of Laboratory Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA.
出版信息
Am Heart J. 2013 Jun;165(6):995-9. doi: 10.1016/j.ahj.2013.02.029. Epub 2013 Apr 6.
BACKGROUND
Galectin-3 and soluble ST2 (sST2) are novel serum biomarkers of chronic heart failure.
METHODS AND RESULTS
The biological variability of galectin-3 and sST2 was measured from a cohort of 17 healthy subjects where blood was taken once every 2 weeks for 8 weeks (n = 4 samples) and from 12 subjects where blood was taken hourly (for galectin-3 only). The analytical, intraindividual, and interindividual variation were measured for galectin-3 (BG Medicine, Waltham, MA) and sST2 (Critical Diagnostics, San Diego, CA). From these measurements, the reference change (RCV) and index of individuality was 39% (hourly) and 61% (weekly) and 1.0 (hourly and weekly) for galectin-3. Corresponding RCV and index of individuality values for sST2 were 30% and 0.25.
CONCLUSION
The RCV result for sST2 was lower than the corresponding results for galectin-3, B-type natriuretic peptide, and N-terminal pro-B-type natriuretic peptide. These data suggest that sST2 may be more useful for monitoring long-term heart failure, and galectin-3 may be more useful for the diagnosis of heart failure remodeling.
背景
半乳糖凝集素-3 和可溶性 ST2（sST2）是慢性心力衰竭的新型血清生物标志物。
方法和结果
从 17 名健康受试者的队列中测量了半乳糖凝集素-3 和 sST2 的生物学变异性，这些受试者每 2 周采集一次血液，共采集 8 周（n = 4 个样本），其中 12 名受试者每小时采集一次血液（仅用于半乳糖凝集素-3）。对半乳糖凝集素-3（BG Medicine，马萨诸塞州沃尔瑟姆）和 sST2（Critical Diagnostics，圣地亚哥）进行了分析、个体内和个体间变异的测量。从这些测量中，半乳糖凝集素-3 的参考变化值（RCV）和个体指数为 39%（每小时）和 61%（每周），1.0（每小时和每周）。sST2 的相应 RCV 和个体指数值为 30%和 0.25。
结论
sST2 的 RCV 结果低于半乳糖凝集素-3、B 型利钠肽和 N 末端 pro-B 型利钠肽的相应结果。这些数据表明，sST2 可能更有助于监测慢性心力衰竭，而半乳糖凝集素-3 可能更有助于心力衰竭重构的诊断。
Zotero 插件